Product Name
TMC1, Polyclonal Antibody
Popular Item
Full Product Name
TMC1 Polyclonal Antibody
Product Synonym Names
DFNB7; DFNA36; DFNB11
Product Gene Name
anti-TMC1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8TDI8
Purity/Purification
Affinity purification
Immunogen
A synthetic peptide of human TMC1
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-TMC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TMC1 antibody
This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness.
Product Categories/Family for anti-TMC1 antibody
Polyclonal
Applications Tested/Suitable for anti-TMC1 antibody
Western Blot (WB)
Application Notes for anti-TMC1 antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-TMC1 antibody
Western blot analysis of extracts of mouse eye, using TMC1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 90s.
Immunohistochemistry (IHC) of anti-TMC1 antibody
Immunohistochemistry of paraffin-embedded rat brain using TMC1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry (IHC) of anti-TMC1 antibody
Immunohistochemistry of paraffin-embedded human prostate using TMC1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry (IHC) of anti-TMC1 antibody
Immunohistochemistry of paraffin-embedded human esophagus using TMC1 antibody at dilution of 1:100 (40x lens).
NCBI/Uniprot data below describe general gene information for TMC1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_619636.2
[Other Products]
NCBI GenBank Nucleotide #
NM_138691.2
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UniProt Primary Accession #
Q8TDI8
[Other Products]
UniProt Secondary Accession #
A8MVZ2; B1AM91[Other Products]
UniProt Related Accession #
Q8TDI8[Other Products]
Molecular Weight
Calculated MW: 88kDa
Molecular Weight: 760
NCBI Official Full Name
transmembrane channel-like protein 1
NCBI Official Synonym Full Names
transmembrane channel like 1
NCBI Official Symbol
TMC1??[Similar Products]
NCBI Official Synonym Symbols
DFNB7; DFNA36; DFNB11
??[Similar Products]
NCBI Protein Information
transmembrane channel-like protein 1
UniProt Protein Name
Transmembrane channel-like protein 1
UniProt Synonym Protein Names
Transmembrane cochlear-expressed protein 1
Protein Family
AN1-type zinc finger protein
UniProt Gene Name
TMC1??[Similar Products]
UniProt Entry Name
TMC1_HUMAN
NCBI Summary for TMC1
This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]
UniProt Comments for TMC1
TMC1: Required for the normal function of cochlear hair cells. Defects in TMC1 are the cause of deafness autosomal dominant type 36 (DFNA36). DFNA36 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA36 is a bilateral hearing loss, and begins at 5-10 years of age. It progresses to profound deafness within 10-15 years. Defects in TMC1 are the cause of deafness autosomal recessive type 7 (DFNB7); also known as autosomal recessive neurosensory deafness type 11 (DFNB11). This hearing loss is congenital and profound. Belongs to the TMC family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9q21.12
Cellular Component: external side of plasma membrane; integral to membrane; stereocilium bundle tip
Molecular Function: voltage-gated calcium channel activity
Biological Process: auditory receptor cell development; detection of mechanical stimulus involved in sensory perception of sound; vestibular reflex
Disease: Deafness, Autosomal Dominant 36; Deafness, Autosomal Recessive 7
Research Articles on TMC1
1. The first mutation in the TMC1 gene in the Moroccan population causing non-syndromic hearing loss.
Precautions
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Disclaimer
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