Goat Polyclonal (IgG) to Human APOB/Apolipoprotein B; APOB; ApoB-100; Apolipoprotein B-48; ApoB-48; Apolipoprotein B; FLDB; LDLCQ4; Mutant Apo B 100; Apo B-100; Apolipoprotein B-100; Apolipoprotein B48

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Human Apolipoprotein B.

Immunoaffinity Purified

10 mM sodium phosphate, 0.15 M sodium chloride, pH 7.2, 0.05% sodium azide.

Store at 2 degree C to 8 degree C.

Small volumes of anti-APOB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

(ApoB) is the main apolipoprotein of chylomicrons and low densitylipoproteins (LDL). The protein occurs in the plasma in 2 main isoforms, apoB-48 and apoB-100. The first is synthesized exclusively by the gut, the second by the liver. The intestinal (B-48) and hepatic (B-100) formsof apoB are coded by a single gene and by a single mRNA transcriptlarger than 16 kb. The 2 proteins share a common amino terminalsequence.

ELISA (EIA), Flow Cytometry (FC/FACS), Immunodiffusion (ID), Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP), Western Blot (WB)

IHC-P: 5 ug/ml

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

515,605 Da

apolipoprotein B

apolipoprotein B-100

Apolipoprotein B-100

Apo B-100; Apo B-48??[Similar Products]

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

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