Product Name
Apolipoprotein B (APOB), Polyclonal Antibody
Full Product Name
Anti-Apolipoprotein B Antibody
Product Synonym Names
Apolipoprotein B-100; Apo B-100
Product Gene Name
anti-APOB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P04114
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of Apolipoprotein B protein.
Purity/Purification
Purified by immunogen affinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human Apolipoprotein B
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-APOB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-APOB antibody
Rabbit polyclonal antibody to Apolipoprotein B
Applications Tested/Suitable for anti-APOB antibody
Western Blot (WB)
Application Notes for anti-APOB antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-APOB antibody
Western blot analysis of Apolipoprotein B expression in HepG2 (A), HL60 (B), mouse liver (C), rat kidney (D) whole cell lysates.
NCBI/Uniprot data below describe general gene information for APOB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000375.2
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NCBI GenBank Nucleotide #
NM_000384.2
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UniProt Primary Accession #
P04114
[Other Products]
UniProt Secondary Accession #
O00502; P78479; P78480; P78481; Q13779; Q13785; Q13786; Q13787; Q13788; Q4ZG63; Q53QC8[Other Products]
UniProt Related Accession #
P04114[Other Products]
Molecular Weight
515,605 Da
NCBI Official Full Name
apolipoprotein B-100
NCBI Official Synonym Full Names
apolipoprotein B
NCBI Official Symbol
APOB??[Similar Products]
NCBI Official Synonym Symbols
FLDB; LDLCQ4; apoB-48; apoB-100
??[Similar Products]
NCBI Protein Information
apolipoprotein B-100
UniProt Protein Name
Apolipoprotein B-100
Protein Family
Apolipoprotein
UniProt Gene Name
APOB??[Similar Products]
UniProt Synonym Gene Names
Apo B-100; Apo B-48??[Similar Products]
NCBI Summary for APOB
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]
UniProt Comments for APOB
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
Research Articles on APOB
1. These findings indicate that maternal apo B levels are significantly associated with apo B levels in their pre-school age children, adjusted for confounding variables. Furthermore, the mother-child correlations in apo B levels were independent of mother-child adiposity. Measurement of apo B levels in mothers may identify both high-risk children and mothers who may benefit from intervention.
Precautions
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Disclaimer
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