Product Name
ATP-sensitive inward rectifier potassium channel 11 (KCNJ11), Recombinant Protein
Full Product Name
Recombinant Guinea pig ATP-sensitive inward rectifier potassium channel 11 (KCNJ11)
Product Gene Name
KCNJ11 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-390aa; full length protein
Sequence
MLSRKGIIPE EYVLTRLAED PTEPRYRARE RRARFVSKKG NCNVAHKNIR EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMVW WLIAFAHGDL APGEGTTVPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI VQNIVGLMIN AIMLGCIFMK TSQAHRRAET LIFSKHAVIA LRHGRLCFML RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF LVAPLIIYHV IDANSPLYDL GPSDLHHHQD LEIIVILEGV VETTGITTQA RTSYLADEIL WGHRFVPIVA EEDGRYSVDY SKFGNTIKVP TPLCTAHQLD EDHSLLDALT LASTRGPLRK RSVPVAKAKP RFSISPDSLS
3D Structure
ModBase 3D Structure for Q9JHJ9
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of KCNJ11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for KCNJ11 recombinant protein
Transmembrane Protein
Application Notes for KCNJ11 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for KCNJ11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001166445.1
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NCBI GenBank Nucleotide #
NM_001172974.1
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UniProt Primary Accession #
Q9JHJ9
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UniProt Related Accession #
Q9JHJ9[Other Products]
Molecular Weight
43,574 Da
NCBI Official Full Name
ATP-sensitive inward rectifier potassium channel 11
NCBI Official Symbol
Kcnj11??[Similar Products]
NCBI Protein Information
ATP-sensitive inward rectifier potassium channel 11
UniProt Protein Name
ATP-sensitive inward rectifier potassium channel 11
UniProt Synonym Protein Names
IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11
Protein Family
ATP-sensitive inward rectifier potassium channel
UniProt Gene Name
KCNJ11??[Similar Products]
UniProt Entry Name
KCJ11_CAVPO
UniProt Comments for KCNJ11
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation ().
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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