Product Name
CFHR3, Recombinant Protein
Full Product Name
Recombinant Human CFHR3 Protein (C-His)
Product Synonym Names
Complement factor H-related protein 3; FHR-3; DOWN16; H factor-like protein 3; CFHR3; CFHL3
Product Gene Name
CFHR3 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q02985
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
Endotoxin
< 1.0 EU per mug as determined by the LAL method.
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of CFHR3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CFHR3 recombinant protein
Protein Construction: Recombinant Human CFHR3 is produced by our mammalian expression system and the target gene encoding Gln19-Glu330 is expressed with a 6His tag at the C-terminus.
Background: Complement factor H-related protein 3 is a protein that in humans is encoded by the CFHR3 gene. It is a secreted protein that belongs to the complement factor H protein family. Members of the H-related protein family are exclusively composed of individually folded protein domains. CFHR3 is synthesized as a 330 amino acid precursor that contains an 18 amino acid signal peptide and a 312 amino acid mature chain. Human CFCR3 protein might be involved in complement regulation.
NCBI/Uniprot data below describe general gene information for CFHR3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001160096.1
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NCBI GenBank Nucleotide #
NP_001160096.1
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UniProt Primary Accession #
Q02985
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UniProt Related Accession #
Q02985[Other Products]
Molecular Weight
Molecular Mass: 36.4kDa
Actual Protein?Molecular Mass: 43-56kDa
NCBI Official Full Name
complement factor H-related protein 3 isoform 2
NCBI Official Synonym Full Names
complement factor H related 3
NCBI Official Symbol
CFHR3??[Similar Products]
NCBI Official Synonym Symbols
FHR3; HLF4; CFHL3; FHR-3; DOWN16
??[Similar Products]
NCBI Protein Information
complement factor H-related protein 3
UniProt Protein Name
Complement factor H-related protein 3
UniProt Synonym Protein Names
DOWN16; H factor-like protein 3
Protein Family
Complement factor H-related protein
UniProt Gene Name
CFHR3??[Similar Products]
UniProt Synonym Gene Names
CFHL3; FHR3; FHR-3??[Similar Products]
NCBI Summary for CFHR3
The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an increased risk of atypical hemolytic-uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for CFHR3
Might be involved in complement regulation.
Research Articles on CFHR3
1. In conclusion, the CFHR3,1D genotype did not associate with progression toward CKD stages 3 and 5 in our white population of patients with IgAN, although it did associate with a reduced level of glomerular immune deposits.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
