Product Name
Transmembrane channel-like protein 1 (TMC1), Recombinant Protein
Full Product Name
Recombinant Human Transmembrane channel-like protein 1 (TMC1)
Product Gene Name
TMC1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-760aa; full length protein
Sequence
MSPKKVQIKV EEKEDETEES SSEEEEEVED KLPRRESLRP KRKRTRDVIN EDDPEPEPED EETRKAREKE RRRRLKRGAE EEEIDEEELE RLKAELDEKR QIIATVKCKP WKMEKKIEVL KEAKKFVSEN EGALGKGKGK RWFAFKMMMA KKWAKFLRDF ENFKAACVPW ENKIKAIESQ FGSSVASYFL FLRWMYGVNM VLFILTFSLI MLPEYLWGLP YGSLPRKTVP RAEEASAANF GVLYDFNGLA QYSVLFYGYY DNKRTIGWMN FRLPLSYFLV GIMCIGYSFL VVLKAMTKNI GDDGGGDDNT FNFSWKVFTS WDYLIGNPET ADNKFNSITM NFKEAITEEK AAQVEENVHL IRFLRFLANF FVFLTLGGSG YLIFWAVKRS QEFAQQDPDT LGWWEKNEMN MVMSLLGMFC PTLFDLFAEL EDYHPLIALK WLLGRIFALL LGNLYVFILA LMDEINNKIE EEKLVKANIT LWEANMIKAY NASFSENSTG PPFFVHPADV PRGPCWETMV GQEFVRLTVS DVLTTYVTIL IGDFLRACFV RFCNYCWCWD LEYGYPSYTE FDISGNVLAL IFNQGMIWMG SFFAPSLPGI NILRLHTSMY FQCWAVMCCN VPEARVFKAS RSNNFYLGML LLILFLSTMP VLYMIVSLPP SFDCGPFSGK NRMFEVIGET LEHDFPSWMA KILRQLSNPG LVIAVILVMV LAIYYLNATA KGQKAANLDL KKKMKMQALE NKMRNKKMAA ARAAAAAGRQ
3D Structure
ModBase 3D Structure for Q8TDI8
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TMC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for TMC1 recombinant protein
Transmembrane Protein
Application Notes for TMC1 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for TMC1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_619636.2
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NCBI GenBank Nucleotide #
NM_138691.2
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UniProt Primary Accession #
Q8TDI8
[Other Products]
UniProt Secondary Accession #
A8MVZ2; B1AM91[Other Products]
UniProt Related Accession #
Q8TDI8[Other Products]
Molecular Weight
87,768 Da
NCBI Official Full Name
transmembrane channel-like protein 1
NCBI Official Synonym Full Names
transmembrane channel like 1
NCBI Official Symbol
TMC1??[Similar Products]
NCBI Official Synonym Symbols
DFNB7; DFNA36; DFNB11
??[Similar Products]
NCBI Protein Information
transmembrane channel-like protein 1
UniProt Protein Name
Transmembrane channel-like protein 1
UniProt Synonym Protein Names
Transmembrane cochlear-expressed protein 1
Protein Family
AN1-type zinc finger protein
UniProt Gene Name
TMC1??[Similar Products]
UniProt Entry Name
TMC1_HUMAN
NCBI Summary for TMC1
This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]
UniProt Comments for TMC1
TMC1: Required for the normal function of cochlear hair cells. Defects in TMC1 are the cause of deafness autosomal dominant type 36 (DFNA36). DFNA36 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA36 is a bilateral hearing loss, and begins at 5-10 years of age. It progresses to profound deafness within 10-15 years. Defects in TMC1 are the cause of deafness autosomal recessive type 7 (DFNB7); also known as autosomal recessive neurosensory deafness type 11 (DFNB11). This hearing loss is congenital and profound. Belongs to the TMC family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9q21.12
Cellular Component: external side of plasma membrane; integral to membrane; stereocilium bundle tip
Molecular Function: voltage-gated calcium channel activity
Biological Process: auditory receptor cell development; detection of mechanical stimulus involved in sensory perception of sound; vestibular reflex
Disease: Deafness, Autosomal Dominant 36; Deafness, Autosomal Recessive 7
Research Articles on TMC1
1. The first mutation in the TMC1 gene in the Moroccan population causing non-syndromic hearing loss.
Precautions
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Disclaimer
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