Product Name
Transmembrane channel-like protein 1 (Tmc1), Recombinant Protein
Full Product Name
Recombinant Mouse Transmembrane channel-like protein 1 (Tmc1)
Product Gene Name
Tmc1 recombinant protein
[Similar Products]
Product Synonym Gene Name
Bth; dn[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-757. Full Length
Sequence
MLQIQVEEKE EDTEESSSEE EEDKLPRRES LRPKRKRTRD VINEDDPEPE PEDEETRKAR EKERRRRLRR GAEEEEEIDE EELERLKALL DENRQMIATV KCKPWKMEKK IEVLKEAKKF VSENEGALGK GKGKKWFAFK MMMAKKWAKF LRDFENFKAA CVPWENKIKA IESQFGSSVA SYFLFLRWMY GVNMVLFVLT FSLIMLPEYL WGLPYGSLPR KTVPRAEEAS AANFGVLYDF NGLAQYSVLF YGYYDNKRTI GWLNFRLPLS YFLVGIMCIG YSFLVVLKAM TKNIGDDGGG DDNTFNFSWK VFCSWDYLIG NPETADNKFN SITMNFKEAI IEERAAQVEE NIHLIRFLRF LANFFVFLTL GASGYLIFWA VKRSQEFAQQ DPDTLGWWEK NEMNMVMSLL GMFCPTLFDL FAELEDYHPL IALKWLLGRI FALLLGNLYV FILALMDEIN NKIEEEKLVK ANITLWEANM IKAYNESLSG LSGNTTGAPF FVHPADVPRG PCWETMVGQE FVRLTVSDVL TTYVTILIGD FLRACFVRFC NYCWCWDLEY GYPSYTEFDI SGNVLALIFN QGMIWMGSFF APSLPGINIL RLHTSMYFQC WAVMCCNVPE ARVFKASRSN NFYLGMLLLI LFLSTMPVLY MIVSLPPSFD CGPFSGKNRM FEVIGETLEH DFPSWMAKIL RQLSNPGLVI AVILVMVLTI YYLNATAKGQ KAANLDLKKK MKQQALENKM RNKKMAAARA AAAAGGQ
3D Structure
ModBase 3D Structure for Q8R4P5
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Tmc1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Tmc1 recombinant protein
Transmembrane Protein
Application Notes for Tmc1 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Tmc1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_083229.1
[Other Products]
NCBI GenBank Nucleotide #
NM_028953.2
[Other Products]
UniProt Primary Accession #
Q8R4P5
[Other Products]
UniProt Secondary Accession #
Q7TQB2; Q9D435[Other Products]
UniProt Related Accession #
Q8R4P5[Other Products]
Molecular Weight
31,965 Da
NCBI Official Full Name
transmembrane channel-like protein 1
NCBI Official Synonym Full Names
transmembrane channel-like gene family 1
NCBI Official Symbol
Tmc1??[Similar Products]
NCBI Official Synonym Symbols
dn; Bth; CWEA1; Beethoven; 4933416G09Rik
??[Similar Products]
NCBI Protein Information
transmembrane channel-like protein 1
UniProt Protein Name
Transmembrane channel-like protein 1
UniProt Synonym Protein Names
Beethoven protein; Deafness protein; Transmembrane cochlear-expressed protein 1
Protein Family
AN1-type zinc finger protein
UniProt Gene Name
Tmc1??[Similar Products]
UniProt Synonym Gene Names
Bth; dn??[Similar Products]
UniProt Entry Name
TMC1_MOUSE
UniProt Comments for Tmc1
TMC1: Required for the normal function of cochlear hair cells. Defects in TMC1 are the cause of deafness autosomal dominant type 36 (DFNA36). DFNA36 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA36 is a bilateral hearing loss, and begins at 5-10 years of age. It progresses to profound deafness within 10-15 years. Defects in TMC1 are the cause of deafness autosomal recessive type 7 (DFNB7); also known as autosomal recessive neurosensory deafness type 11 (DFNB11). This hearing loss is congenital and profound. Belongs to the TMC family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: external side of plasma membrane; integral to membrane; membrane; stereocilium bundle tip
Molecular Function: voltage-gated calcium channel activity
Biological Process: auditory receptor cell development; detection of mechanical stimulus involved in sensory perception of sound; ion transport; sensory perception of sound; transport; vestibular reflex
Disease: Deafness, Autosomal Recessive 7
Research Articles on Tmc1
1. gene augmentation with Tmc1 or Tmc2 is well suited for further development as a strategy for restoration of auditory function in deaf patients who carry TMC1 mutations
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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