Product Name
Adseverin (Scin), Recombinant Protein
Full Product Name
Recombinant Mouse Adseverin (Scin)
Product Gene Name
Scin recombinant protein
[Similar Products]
Product Synonym Gene Name
Scin[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-715aa, full length protein
Sequence
MAQELQHPEF ARAGQQAGLQ VWRVEKLELV PVPQGAYGDF YVGDAYLVLH TTKSSRGFSY RLHFWLGKEC SQDESTAAAI FTVQMDDYLG GKPVQSRELQ GYESTDFVGY FKGGLKYKAG GVASGLNHVL TNDLTAKRLL HVKGRRVVRA TEVPLSWESF NKGDCFIIDL GTEIYQWCGS SCNKYERLKA SQVAIGIRDN ERKGRSQLIV VEEGSEPSEL MKVLGRKPEL PDGDNDDDVV ADISNRKMAK LYMVSDASGS MKVTLVAEEN PFSMGMLLSE ECFILDHGAA KQIFVWKGKN ANPQERKTAM KTAEEFLQKM KYSTNTQIQV LPEGGETPIF KQFFKDWKDK DQSDGFGKVY ITEKVAQIKQ IPFDASKLHS SPQMAAQHNM VDDGSGGVEI WRVENSGRVQ IDPSSYGEFY GGDCYIILYT YPRGQIIYTW QGANATRDEL TMSAFLTVQL DRSLGGQAVQ VRVSQGKEPA HLLSLFKDKP LIIYKNGTSK KEGQAPAPPT RLFQVRRNLA SITRIVEVDV DANSLNSNDT FVLKLPRNNG FIWIGKGASQ EEEKGAEYVA DVLKCKASRI QEGKEPEEFW NSLGGRGDYQ TSPLLETRAE DHPPRLYGCS NKTGRFIIEE VPGEFTQDDL AEDDVMLLDA WEQIFIWIGK DANEVEKKES VKSAKMYLET DPSGRDKRTP IVIIKQGHEP PTFTGWFLGW DSSRW
3D Structure
ModBase 3D Structure for Q60604
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Scin recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Scin. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001139668.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001146196.1
[Other Products]
UniProt Primary Accession #
Q60604
[Other Products]
UniProt Secondary Accession #
O08988; O08990; Q6P4N8[Other Products]
UniProt Related Accession #
Q60604[Other Products]
Molecular Weight
69,110 Da
NCBI Official Full Name
adseverin isoform 1
NCBI Official Synonym Full Names
scinderin
NCBI Official Symbol
Scin??[Similar Products]
NCBI Official Synonym Symbols
AW545522; adseverin
??[Similar Products]
NCBI Protein Information
adseverin
UniProt Protein Name
Adseverin
UniProt Synonym Protein Names
Gelsolin-like protein; Scinderin
UniProt Gene Name
Scin??[Similar Products]
UniProt Comments for Scin
Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:9671468). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (). In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+ (PubMed:9671468). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (PubMed:25275604, PubMed:25681458). Regulates chondrocyte proliferation and differentiation (). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways ().
Research Articles on Scin
1. Adseverin knockdown also suppressed the RANKL-mediated induction of nuclear factor of activated T-cell c1 (NFATc1), which is a key transcription factor in osteoclastogenesis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
