Product Name
Arachidonate 12-lipoxygenase, 12S-type (ALOX12), Recombinant Protein
Full Product Name
Recombinant Rabbit Arachidonate 12-lipoxygenase, 12S-type (ALOX12)
Product Synonym Names
Recombinant Arachidonate 12-lipoxygenase, 12S-type (ALOX12); Arachidonate 12-lipoxygenase, 12S-type; 12S-LOX; 12S-lipoxygenase EC= 1.13.11.31
Product Gene Name
ALOX12 recombinant protein
[Similar Products]
Product Synonym Gene Name
ALOX12[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
GVYRVCVSTG ASIYAGSKNK VELWLVGQHG EVELGSCLRP SRNKEEEFKV NVSKYLGSLL FVKLRKKHFL KEDAWFCNWI SVQALGAAED KYWFPCYRWV VGDGVQSLPV GTGCTTVGDP QGLFQKHREQ ELEERRKLYQ WGSWKEGLIL NVAGSKLTDL PVDERFLEDK KIDFEASLAW GLAELALKNS LNILAPWKTL DDFNRIFWCG RSKLARRVRD SWQEDSLFGY QFLNGANPML LRRSVQLPAR LVFPPGMEEL QAQLEKELKA GTLFEADFAL LDNIKANVIL YCQQYLAAPL VMLKLQPDGK LMPMVIQLHL PKIGSSPPPL FLPTDPPMVW LLAKCWVRSS DLQVHELNSH LLRGHLMAEV FTVATMRCLP SIHPVFKLIV PHLRYTLEIN VRARNGLVSD FGIFDQIMST GGGGHVQLLQ QAGAFLTYRS FCPPDDLADR GLLGVESSFY AQDALRLWEI ISRYVQGIMG LYYKTDEAVR DDLELQSWCR EITEIGLQGA QKQGFPTSLQ SVAQACHFVT MCIFTCTGQH SSIHLGQLDW FTWVPNAPCT MRLPPPTTKD ATLETVMATL PNLHQSSLQM SIVWQLGRDQ PIMVPLGQHQ EEYFSGPEPR AVLEKFREEL AIMDKEIEVR NEKLDIPYEY LRPSIVENSV AI
3D Structure
ModBase 3D Structure for O19043
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Oryctolagus cuniculus (Rabbit)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ALOX12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ALOX12. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001139620.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001146148.1
[Other Products]
UniProt Primary Accession #
O19043
[Other Products]
UniProt Related Accession #
O19043[Other Products]
Molecular Weight
75,234 Da[Similar Products]
NCBI Official Full Name
arachidonate 12-lipoxygenase, 12S-type
NCBI Official Symbol
ALOX12??[Similar Products]
NCBI Official Synonym Symbols
12-LOX
??[Similar Products]
NCBI Protein Information
arachidonate 12-lipoxygenase, 12S-type; 12S-LOX; 12S-lipoxygenase
UniProt Protein Name
Arachidonate 12-lipoxygenase, 12S-type
Protein Family
Arachidonate 12-lipoxygenase
UniProt Gene Name
ALOX12??[Similar Products]
UniProt Synonym Gene Names
12S-LOX??[Similar Products]
UniProt Entry Name
LOX12_RABIT
UniProt Comments for ALOX12
Function: Oxygenase and 14,15-leukotriene A4 synthase activity. Ref.1
Catalytic activity: Arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
Cofactor: Binds 1 iron ion per subunit.
Pathway: Lipid metabolism; leukotriene D4 biosynthesis.
Subcellular location: Cytoplasm.
Sequence similarities: Belongs to the lipoxygenase family.Contains 1 lipoxygenase domain.Contains 1 PLAT domain.
Research Articles on ALOX12
1. The conserved residue Leu597 actually drives the regiospecific hydroperoxidation of linoleic acid catalyzed by 15-lipoxygenase enzyme.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
