Product Name
BPIFA1, Recombinant Protein
Full Product Name
Purified recombinant Human BPIFA1 protein (His tag)
Product Synonym Names
BPIFA1 protein (His tag)
Product Gene Name
BPIFA1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
21-137aa: MGSSHHHHHH SSGLVPRGSH MGSQFGGLPV PLDQTLPLNV NPALPLSPTG LAGSLTNALS NGLLSGGLLG ILENLPLLDI LKPGGGTSGG LLGGLLGKVT SVIPGLNNII DIKVTDPQLL ELGLVQSPDG HRLYVTIPLG IKLQVNTPLV GASLLRLAVK LDITAEILAV RDKQERIHLV LGDCTHSPGS LQISLLDGLG PLPIQGLLDS LTGILNKVLP ELVQGNVCPL VNEVLRGLDI TLVHDIVNML IHGLQFVIKV
OMIM
AF214562 Genomic DNA
3D Structure
ModBase 3D Structure for Q9NP55
Purity/Purification
> 90% pure
Form/Format
Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% glycerol
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of BPIFA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for BPIFA1 recombinant protein
Immunology
Applications Tested/Suitable for BPIFA1 recombinant protein
SDS-PAGE
SDS-Page of BPIFA1 recombinant protein
Figure annotation denotes ug of protein loaded and % gel used.
NCBI/Uniprot data below describe general gene information for BPIFA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001230122.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001243193.1
[Other Products]
UniProt Primary Accession #
Q9NP55
[Other Products]
UniProt Secondary Accession #
Q9NZT0; A6XMV5; A8K9R3; E1P5M9[Other Products]
UniProt Related Accession #
Q9NP55[Other Products]
Molecular Weight
25,257 Da
NCBI Official Full Name
BPI fold-containing family A member 1
NCBI Official Synonym Full Names
BPI fold containing family A member 1
NCBI Official Symbol
BPIFA1??[Similar Products]
NCBI Official Synonym Symbols
LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5
??[Similar Products]
NCBI Protein Information
BPI fold-containing family A member 1
UniProt Protein Name
BPI fold-containing family A member 1
UniProt Synonym Protein Names
Lung-specific protein X; Nasopharyngeal carcinoma-related protein; Palate lung and nasal epithelium clone protein; Secretory protein in upper respiratory tracts; Short PLUNC1; SPLUNC1; Tracheal epithelium-enriched protein; Von Ebner protein Hl
Protein Family
BPI fold-containing family
UniProt Gene Name
BPIFA1??[Similar Products]
UniProt Synonym Gene Names
LUNX; NASG; PLUNC; SPLUNC1; SPURT; SPLUNC1??[Similar Products]
NCBI Summary for BPIFA1
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]
UniProt Comments for BPIFA1
PLUNC: May be involved in the airway inflammatory response after exposure to irritants. May be associated with tumor progression. May play a role in innate immune responses of the upper airways. Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20q11.21
Cellular Component: extracellular region; extracellular space
Molecular Function: protein binding
Biological Process: antibacterial humoral response; innate immune response; multicellular organismal water homeostasis; regulation of liquid surface tension
Research Articles on BPIFA1
1. These studies identify the role of SPLUNC1 in sinonasal innate immunity and the pathogenesis of CRS. Defective expression of SPLUNC1 in CRSwNP patients may lead to insufficient maintenance of the epithelial barrier function
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
