Product Name
BOLL, Blocking Peptide
Product Synonym Names
Protein boule-like; BOLL; BOULE
Product Gene Name
BOLL blocking peptide
[Similar Products]
Product Synonym Gene Name
BOULE[Similar Products]
Antibody/Peptide Pairs
BOLL peptide (MBS9221621) is used for blocking the activity of BOLL antibody (MBS9212161)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8N9W6
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm
Tissue Location
Testis specific. Not expressed in early embryos, primordial germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of BOLL blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
BOLL blocking peptide
Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity).
NCBI/Uniprot data below describe general gene information for BOLL. It may not necessarily be applicable to this product.
NCBI Accession #
Q8N9W6.2
[Other Products]
UniProt Primary Accession #
Q8N9W6
[Other Products]
UniProt Secondary Accession #
Q0JW32; Q53T62; Q969U3; B4DZA4[Other Products]
UniProt Related Accession #
Q8N9W6[Other Products]
Molecular Weight
19,256 Da
NCBI Official Full Name
Protein boule-like
NCBI Official Synonym Full Names
boule homolog, RNA binding protein
NCBI Official Symbol
BOLL??[Similar Products]
NCBI Official Synonym Symbols
BOULE
??[Similar Products]
NCBI Protein Information
protein boule-like
UniProt Protein Name
Protein boule-like
Protein Family
Protein boule
UniProt Gene Name
BOLL??[Similar Products]
UniProt Synonym Gene Names
BOULE??[Similar Products]
UniProt Entry Name
BOLL_HUMAN
NCBI Summary for BOLL
This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for BOLL
BOLL: Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Belongs to the RRM DAZ family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Translation
Chromosomal Location of Human Ortholog: 2q33
Cellular Component: cytoplasm
Molecular Function: protein binding; translation activator activity
Biological Process: meiosis; positive regulation of translational initiation
Research Articles on BOLL
1. Our study demonstrated an oncogenic role of BOLL in CRC despite tumor-specific promoter hypermethylation.
Precautions
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Disclaimer
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