Product Name
BPIFA1, Polyclonal Antibody
Popular Item
Full Product Name
BPIFA1 Polyclonal Antibody
Product Synonym Names
LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5
Product Gene Name
anti-BPIFA1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NP55
Species Reactivity
Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human BPIFA1
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-BPIFA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BPIFA1 antibody
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known.
Product Categories/Family for anti-BPIFA1 antibody
Polyclonal
Applications Tested/Suitable for anti-BPIFA1 antibody
Western Blot (WB)
Application Notes for anti-BPIFA1 antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-BPIFA1 antibody
Western blot analysis of extracts of various cell lines, using BPIFA1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 1s.
NCBI/Uniprot data below describe general gene information for BPIFA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001230122.1
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NCBI GenBank Nucleotide #
NM_001243193.1
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UniProt Primary Accession #
Q9NP55
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UniProt Secondary Accession #
Q9NZT0; A6XMV5; A8K9R3; E1P5M9[Other Products]
UniProt Related Accession #
Q9NP55[Other Products]
Molecular Weight
Calculated MW: 27kDa
Molecular Weight: 256
NCBI Official Full Name
BPI fold-containing family A member 1
NCBI Official Synonym Full Names
BPI fold containing family A member 1
NCBI Official Symbol
BPIFA1??[Similar Products]
NCBI Official Synonym Symbols
LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5
??[Similar Products]
NCBI Protein Information
BPI fold-containing family A member 1
UniProt Protein Name
BPI fold-containing family A member 1
UniProt Synonym Protein Names
Lung-specific protein X; Nasopharyngeal carcinoma-related protein; Palate lung and nasal epithelium clone protein; Secretory protein in upper respiratory tracts; Short PLUNC1; SPLUNC1; Tracheal epithelium-enriched protein; Von Ebner protein Hl
Protein Family
BPI fold-containing family
UniProt Gene Name
BPIFA1??[Similar Products]
UniProt Synonym Gene Names
LUNX; NASG; PLUNC; SPLUNC1; SPURT; SPLUNC1??[Similar Products]
UniProt Entry Name
BPIA1_HUMAN
NCBI Summary for BPIFA1
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]
UniProt Comments for BPIFA1
PLUNC: May be involved in the airway inflammatory response after exposure to irritants. May be associated with tumor progression. May play a role in innate immune responses of the upper airways. Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 20q11.2
Cellular Component: extracellular region; extracellular space
Molecular Function: lipid binding; protein binding
Biological Process: antibacterial humoral response; innate immune response; multicellular organismal water homeostasis; regulation of liquid surface tension
Research Articles on BPIFA1
1. PLUNC is a protein of the tear film and suggest that it plays a role in fluid balance and surface tension regulation at the ocular surface.
Precautions
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Disclaimer
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