Product Name
IL-31 (IL31), Polyclonal Antibody
Full Product Name
RABBIT ANTI HUMAN INTERLEUKIN-31
Product Gene Name
anti-IL31 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6EBC2
Form/Format
Purified
Purified IgG - lyophilised
Concentration
IgG concentration 1.0mg/ml (lot specific)
Reconstitution
Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended.
Immunogen
Recombinant human IL-31.
Buffer Solution
Antiserum Preparation
Antisera to human IL-31 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Preparation and Storage
Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
Other Notes
Small volumes of anti-IL31 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IL31 antibody
Rabbit anti Human Interleukin-31 antibody recognizes human IL-31 (interleukin-31), a 141 amino acid T-cell derived cytokine and member of the IL-6 cytokine family, which shares homology with oncostatin M, cardiotrophin-1 and LIF (leukaemia inhibitory factor)..IL-31 is preferentially produced by type 2 helper T cells (Th2) and signals through binding to the IL-31 receptor consisting of IL-31 receptor A (IL-31RA/GPL) and oncostatin M receptor B, activators of STAT1, STAT3 and STAT5. IL-31 is an important mediator of T cell mediated immune response and is particularly linked with diseases of the skin, including dermatitis and pruritic atopic skin inflammation, and is also implicated in bronchial inflammation.
Applications Tested/Suitable for anti-IL31 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-IL31 antibody
ELISA: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml;
Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml
NCBI/Uniprot data below describe general gene information for IL31. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001014358.1
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NCBI GenBank Nucleotide #
NM_001014336.1
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UniProt Primary Accession #
Q6EBC2
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UniProt Secondary Accession #
A2RUQ1[Other Products]
UniProt Related Accession #
Q6EBC2[Other Products]
Molecular Weight
18,205 Da[Similar Products]
NCBI Official Full Name
interleukin-31
NCBI Official Synonym Full Names
interleukin 31
NCBI Official Symbol
IL31??[Similar Products]
NCBI Official Synonym Symbols
IL-31
??[Similar Products]
NCBI Protein Information
interleukin-31
UniProt Protein Name
Interleukin-31
Protein Family
Interleukin
UniProt Gene Name
IL31??[Similar Products]
UniProt Synonym Gene Names
IL-31??[Similar Products]
UniProt Entry Name
IL31_HUMAN
NCBI Summary for IL31
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
UniProt Comments for IL31
IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.
Protein type: Secreted; Secreted, signal peptide; Cytokine
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: extracellular space
Molecular Function: cytokine activity
Biological Process: immune system process
Research Articles on IL31
1. IL-31 may play an important role in the pathophysiology of uremic pruritus.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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