Product Name
IL-31, Active Protein
Popular Item
Full Product Name
Recombinant Mouse IL-31
Product Synonym Names
Mouse IL-31; Interleukin-31
Product Gene Name
IL-31 active protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADESIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL TNISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKDNTT C
3D Structure
ModBase 3D Structure for Q6EAL8
Purity/Purification
Purity is typically 97% as determined by reducing and non-reducing SDS-PAGE, UV spectroscopy at 280 nm
Form/Format
Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing
10 mM sodium phosphate, pH 7.5
Bioactivity Assay
bioactive protein but no acceptaince criteria limits established
Reconstitution
Sterile water at 0.1 mg/mL
Acceptance Criteria LAL (EUs/ug)
<=1.00
Endotoxin Level (kinetic LAL analysis)
Typically less than 0.05 EUs/mug protein (50% confidence range)
Biological Activity
The activity is determined by the dose dependent production of IL-8 from human PBMCs and is typically less than 25 ng/mL. This corresponds to an expected specific activity of 4 x 104 units/mg.
Media Components
Luria Broth
Preparation and Storage
12 months from date of receipt when stored at -20 degree C to-80 degree C as supplied.
1 month when stored at 4 degree C after reconstituting as directed.
3 months when stored at -20 degree C to -80 degree C after reconstituting as directed.
Active Protein Note
Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
Other Notes
Small volumes of IL-31 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IL-31 active protein
Interleukin 31 (IL-31) is an immunoregulatory cytokine that is expressed by activated type 2 T helper (Th2) cells. IL-31 signals through a heterodimer receptor consisting of the IL-31 Receptor A (IL-31RA) and the oncostatin M receptor (OSMR), which are expressed on monocytes, epithelial cells, and keratinocytes. IL-31 promotes allergic reactions and inflammatory skin diseases.
Gel Data of IL-31 active protein
Biological Activity of IL-31 active protein
NCBI/Uniprot data below describe general gene information for IL-31. It may not necessarily be applicable to this product.
NCBI Accession #
NP_083870.1
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NCBI GenBank Nucleotide #
NM_029594.1
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UniProt Primary Accession #
Q6EAL8
[Other Products]
UniProt Related Accession #
Q6EAL8[Other Products]
Molecular Weight
Non-glycosylated protein, containing 141 amino acids, with a molecular weight of 15.7 kDa.
NCBI Official Full Name
interleukin-31
NCBI Official Synonym Full Names
interleukin 31
NCBI Official Symbol
Il31??[Similar Products]
NCBI Official Synonym Symbols
1700013B14Rik
??[Similar Products]
NCBI Protein Information
interleukin-31
UniProt Protein Name
Interleukin-31
UniProt Gene Name
Il31??[Similar Products]
UniProt Synonym Gene Names
IL-31??[Similar Products]
UniProt Comments for IL-31
IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component: extracellular space
Molecular Function: cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; oncostatin-M receptor binding; protein binding
Research Articles on IL-31
1. Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
