Anti -S-Arrestin (S Arrestin, S-arrestin, 48kD Protein, DKFZp686I1383, Rod Photoreceptor Arrestin, S Antigen, S-antigen Retina and Pineal Gland, S AG, SAG, S-AG)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 2; NC_000002.11 (234216309..234255701). Location: 2q37.1

Monoclonal

IgG1

9G8

Mouse

This antibody is specific for arrestin protein. Species Crossreactivity: This antibody reacts with human, bovine, porcine, and rat (weakly).

Purified
Purified

Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 3 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-SAG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

S-antigen, also identified as arrestin, is a protein involved in the regulation of phototransduction.

Antibodies; Abs to Arrestin

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry (Fr).

45,120 Da[Similar Products]

S-antigen; retina and pineal gland (arrestin)

S-arrestin; arrestin 1; 48 kDa protein; OTTHUMP00000203381; rod photoreceptor arrestin; retinal S-antigen (48 KDa protein)

S-arrestin

ARRS_HUMAN

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq]

SAG: Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Retina and pineal gland. Belongs to the arrestin family.

Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: photoreceptor inner segment; photoreceptor outer segment; cytosol

Molecular Function: opsin binding; phosphoprotein binding; protein phosphatase inhibitor activity

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; cell surface receptor linked signal transduction; regulation of rhodopsin mediated signaling; visual perception; negative regulation of catalytic activity

Disease: Oguchi Disease 1; Retinitis Pigmentosa 47

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