For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 3; NC_000003.11 (46899357..46904973, complement). Location: 3p21.3-p21.2

Store all reagents at 2-8 degree C

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Small volumes of CMLC-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9303217 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cardiac myosin-light chains 1, CMLC-1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CMLC-1. The ELISA analytical biochemical technique of the MBS9303217 kit is based on CMLC-1 antibody-CMLC-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CMLC-1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CMLC-1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

21,932 Da

myosin, light chain 3, alkali; ventricular, skeletal, slow

myosin light chain 3; CMLC1; cardiac myosin light chain 1; ventricular/slow twitch myosin alkali light chain; myosin light chain 1, slow-twitch muscle B/ventricular isoform; myosin, light polypeptide 3, alkali; ventricular, skeletal, slow

Myosin light chain 3

CMLC1; MLC1SB??[Similar Products]

MYL3_HUMAN

MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

MYL3: Regulatory light chain of myosin. Does not bind calcium. Defects in MYL3 are the cause of familial hypertrophic cardiomyopathy type 8 (CMH8). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.

Protein type: Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.3-p21.2

Cellular Component: I band; sarcomere; muscle myosin complex; cytosol; A band

Molecular Function: actin monomer binding; structural constituent of muscle; motor activity; myosin II heavy chain binding; calcium ion binding

Biological Process: skeletal muscle development; metabolic process; positive regulation of ATPase activity; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; regulation of the force of heart contraction; muscle filament sliding; cardiac muscle contraction

Disease: Cardiomyopathy, Familial Hypertrophic, 8

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