Product Name
CD40, Recombinant Protein
Full Product Name
Recombinant Mouse CD40
Product Gene Name
CD40 recombinant protein
[Similar Products]
Product Synonym Gene Name
mCD40[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
LGQCVTCSDK QYLHDGQCCD LCQPGSRLTS HCTALEKTQC HPCDSGEFSA QWNREIRCHQ HRHCEPNQGL RVKKEGTAES DTVCTCKEGQ HCTSKDCEAC AQHTPCIPGF GVMEMATETT DTVCHPCPVG FFSNQSSLFE KCYPWTSCED KNLEVLQKGT SQTNVICGLK SRMRHHH HHH
3D Structure
ModBase 3D Structure for P27548
Other Notes
Small volumes of CD40 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for CD40 recombinant protein
RECOMBINANT & NATURAL PROTEINS
NCBI/Uniprot data below describe general gene information for CD40. It may not necessarily be applicable to this product.
NCBI Accession #
NP_035746.2
[Other Products]
NCBI GenBank Nucleotide #
NM_011616.2
[Other Products]
UniProt Primary Accession #
P27548
[Other Products]
UniProt Related Accession #
P27548[Other Products]
Molecular Weight
29,370 Da
NCBI Official Full Name
CD40 ligand
NCBI Official Synonym Full Names
CD40 ligand
NCBI Official Symbol
Cd40lg??[Similar Products]
NCBI Official Synonym Symbols
IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5; Tnlg8b
??[Similar Products]
NCBI Protein Information
CD40 ligand
UniProt Protein Name
CD40 ligand
UniProt Synonym Protein Names
T-cell antigen Gp39; TNF-related activation protein; TRAP
Protein Family
CD40 ligand
UniProt Gene Name
Cd40lg??[Similar Products]
UniProt Synonym Gene Names
Cd40l; Tnfsf5; CD40-L; TRAP??[Similar Products]
UniProt Entry Name
CD40L_MOUSE
UniProt Comments for CD40
CD40LG: Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1); also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. Belongs to the tumor necrosis factor family.
Protein type: Cell adhesion; Membrane protein, integral
Cellular Component: cell projection; cell surface; external side of plasma membrane; extracellular space
Molecular Function: CD40 receptor binding
Biological Process: activation of JNK activity; activation of NF-kappaB transcription factor; B cell differentiation; B cell proliferation; immunoglobulin secretion; inflammatory response; isotype switching; negative regulation of apoptosis; platelet activation; positive regulation of B cell proliferation; positive regulation of immune response to tumor cell; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-4 production; positive regulation of MHC class II biosynthetic process; positive regulation of T cell proliferation; regulation of immunoglobulin secretion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
