Product Name
Interleukin-31 (mIL 31), Recombinant Protein
Full Product Name
Recombinant Mouse Interleukin-31
Product Synonym Names
IL31 Mouse; Interleukin-31 Mouse Recombinant; Interleukin 31; IL31; IL-31
Product Gene Name
mIL 31 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADESIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL TNISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKDNTT C
3D Structure
ModBase 3D Structure for Q6EAL8
Purity/Purification
Greater than 97.0% as determined by(a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE.
Form/Format
The IL31 (1mg/ml) was lyophilized from 10mM sodium Phosphate pH-7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility
It is recommended to reconstitute the lyophilized IL31 in sterile 18M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Preparation and Storage
Lyophilized IL31 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL31 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.
Other Notes
Small volumes of mIL 31 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
mIL 31 recombinant protein
Description: IL31 mouse recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 141 amino acids and having a molecular mass of 15.7 kDa.
Introduction: IL-31 produced by activated Th2-type T cells, cooperates with a heterodimeric receptor consisting of IL-31 Receptor Anatagonist and Onconstatin-M Receptor that is continuesly expressed on epithelial cells and keratinocytes. IL-31 plays a role in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma. IL-31 is involved in the itching sensation and endorses the scratching behavior in NC/Nga mice with atopic dermatitis. IL-31 expression is connectd with CLA(+) T cells and contributes to the development of atopic dermatitis-induced skin inflammation and pruritus. IL-31 is a powerful inducer of proinflammatory mediators in human colonic SEMFs. IL-31 takes part as a proinflammatory cytokine derived from Th2 cells.Serum IL-31 level is higher in patients with atopic dermatitis. IL-31 is involved in a broad range of immune- & non-immune cells & possesses potential pleiotropic physiological functions, including regulating hematopoiesis & immune re
Product Categories/Family for mIL 31 recombinant protein
CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
NCBI/Uniprot data below describe general gene information for mIL 31. It may not necessarily be applicable to this product.
NCBI Accession #
NP_083870.1
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NCBI GenBank Nucleotide #
NM_029594.1
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UniProt Primary Accession #
Q6EAL8
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UniProt Related Accession #
Q6EAL8[Other Products]
Molecular Weight
18,120 Da
NCBI Official Full Name
interleukin-31
NCBI Official Synonym Full Names
interleukin 31
NCBI Official Symbol
Il31??[Similar Products]
NCBI Official Synonym Symbols
1700013B14Rik
??[Similar Products]
NCBI Protein Information
interleukin-31; IL-31
UniProt Protein Name
Interleukin-31
Protein Family
Interleukin
UniProt Gene Name
Il31??[Similar Products]
UniProt Synonym Gene Names
IL-31??[Similar Products]
UniProt Entry Name
IL31_MOUSE
UniProt Comments for mIL 31
IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity
Protein type: Secreted; Secreted, signal peptide; Cytokine
Cellular Component: extracellular space; extracellular region
Molecular Function: cytokine activity
Biological Process: immune system process
Research Articles on mIL 31
1. Data not only illustrate various functions that cysteines perform during IL-31 biosynthesis and secretion, but also highlight their potential roles in cytokine effector functions.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
