Full Product Name
KRT10, ID (Keratin, Type I Cytoskeletal 10, Cytokeratin-10, CK-10, Keratin-10, K10, KPP)
Product Synonym Names
Anti -KRT10, ID (Keratin, Type I Cytoskeletal 10, Cytokeratin-10, CK-10, Keratin-10, K10, KPP)
Product Gene Name
anti-KRT10 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (38974369..38978863, complement). Location: 17q21
3D Structure
ModBase 3D Structure for P13645
Specificity
Recognizes human KRT10.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide corresponding to a region between aa325-354 from the center region of human KRT10, conjugated to KLH.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-KRT10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KRT10 antibody
KRT10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in its gene are associated with epidermolytic hyperkeratosis.
Product Categories/Family for anti-KRT10 antibody
Antibodies; Abs to Keratin, Cytokeratin
Applications Tested/Suitable for anti-KRT10 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-KRT10 antibody
Suitable for use in ELISA, Flow Cytometry, Western Blot and Immunohistochemistry.
Dilution: Flow Cytometry: 1:10-1:50
Western Blot: 1:50-1:100
Immunohistochemistry: 1:50-1:100
NCBI/Uniprot data below describe general gene information for KRT10. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000412.3
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NCBI GenBank Nucleotide #
NM_000421.3
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UniProt Primary Accession #
P13645
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UniProt Secondary Accession #
Q14664; Q8N175[Other Products]
UniProt Related Accession #
P13645[Other Products]
Molecular Weight
58,827 Da[Similar Products]
NCBI Official Full Name
keratin, type I cytoskeletal 10
NCBI Official Synonym Full Names
keratin 10
NCBI Official Symbol
KRT10??[Similar Products]
NCBI Official Synonym Symbols
BIE; EHK; K10; KPP; BCIE; CK10
??[Similar Products]
NCBI Protein Information
keratin, type I cytoskeletal 10; CK-10; keratin-10; cytokeratin 10; OTTHUMP00000165049
UniProt Protein Name
Keratin, type I cytoskeletal 10
UniProt Synonym Protein Names
Cytokeratin-10; CK-10; Keratin-10
UniProt Gene Name
KRT10??[Similar Products]
UniProt Synonym Gene Names
KPP??[Similar Products]
UniProt Entry Name
K1C10_HUMAN
NCBI Summary for KRT10
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq]
UniProt Comments for KRT10
K10: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K1.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: extracellular space; membrane; cytoplasm; keratin filament; intermediate filament; nucleus
Molecular Function: structural constituent of epidermis
Biological Process: keratinocyte differentiation
Disease: Erythroderma, Ichthyosiform, Congenital Reticular; Epidermolytic Hyperkeratosis; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis
Research Articles on KRT10
1. mutation analysis in patients with epidermolytic ichthyosis by direct sequencing of KRT1 and KRT10 genes; identified 14 different mutations, of which four have not been published previously
Precautions
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Disclaimer
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