Full Product Name
Anti-MYL3 Mouse mAb
Product Synonym Names
CMH8; VLC1; MLC1V; MLC1SB
Product Gene Name
anti-MYL3 antibody
[Similar Products]
Product Synonym Gene Name
CMH8; VLC1; MLC1V; MLC1SB[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P08590
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Immunogen
Purified recombinant fragment of MYL3 expressed in E Coli.
Other Notes
Small volumes of anti-MYL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MYL3 antibody
Entrez Summary: Myosins are a large superfamily of motor proteins that move along actin filaments, while hydrolyzing ATP. Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains and four light chains. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Human myosin light chain has clinical application as a cardiac marker. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.
Applications Tested/Suitable for anti-MYL3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Western Blot (WB) of anti-MYL3 antibody
Western blot analysis using MYL3 (1) and MYL2 (2) mouse mAb against rat fetal heart tissues lysate.
Immunohistochemistry (IHC) of anti-MYL3 antibody
Immunohistochemical analysis of paraffin-embedded human Heart tissues using MYL3 mouse mAb.
NCBI/Uniprot data below describe general gene information for MYL3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000249.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000258.2
[Other Products]
UniProt Primary Accession #
P08590
[Other Products]
UniProt Secondary Accession #
Q9NRS8; B2R534[Other Products]
UniProt Related Accession #
P08590[Other Products]
NCBI Official Full Name
myosin light chain 3
NCBI Official Synonym Full Names
myosin light chain 3
NCBI Official Symbol
MYL3??[Similar Products]
NCBI Official Synonym Symbols
CMH8; VLC1; VLCl; MLC1V; MLC1SB; MLC-lV/sb
??[Similar Products]
NCBI Protein Information
myosin light chain 3
UniProt Protein Name
Myosin light chain 3
UniProt Synonym Protein Names
Cardiac myosin light chain 1
UniProt Gene Name
MYL3??[Similar Products]
UniProt Synonym Gene Names
MLC-lV/sb??[Similar Products]
NCBI Summary for MYL3
MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Comments for MYL3
MYL3: Regulatory light chain of myosin. Does not bind calcium. Defects in MYL3 are the cause of familial hypertrophic cardiomyopathy type 8 (CMH8). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: A band; cytosol; I band; muscle myosin complex; sarcomere
Molecular Function: actin monomer binding; structural constituent of muscle
Biological Process: cardiac muscle contraction; muscle filament sliding; positive regulation of ATPase activity; regulation of striated muscle contraction; regulation of the force of heart contraction; ventricular cardiac muscle morphogenesis
Disease: Cardiomyopathy, Familial Hypertrophic, 8
Research Articles on MYL3
1. In Familial Hypertrophic Cardiomyopathy, the MYL3 Arg94His variant was associated with high disease penetrance and substantial interventricular septal hypertrophy
Precautions
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Disclaimer
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