Product Name
Cadherin-3 (CDH3), Recombinant Protein
Full Product Name
Cadherin-3
Product Gene Name
CDH3 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
108-829aa; full length protein
Sequence
DWVVAPISVP ENGKGPFPQR LNQLKSNKDR DTKIFYSITG PGADSPPEGV FAVEKETGWL LLNKPLDREE IAKYELFGHA VSENGASVED PMNISIIVTD QNDHKPKFTQ DTFRGSVLEG VLPGTSVMQV TATDEDDAIY TYNGVVAYSI HSQEPKDPHD LMFTIHRSTG TISVISSGLD REKVPEYTLT IQATDMDGDG STTTAVAVVE ILDANDNAPM FDPQKYEAHV PENAVGHEVQ RLTVTDLDAP NSPAWRATYL IMGGDDGDHF TITTHPESNQ GILTTRKGLD FEAKNQHTLY VEVTNEAPFV LKLPTSTATI VVHVEDVNEA PVFVPPSKVV EVQEGIPTGE PVCVYTAEDP DKENQKISYR ILRDPAGWLA MDPDSGQVTA VGTLDREDEQ FVRNNIYEVM VLAMDNGSPP TTGTGTLLLT LIDVNDHGPV PEPRQITICN QSPVRQVLNI TDKDLSPHTS PFQAQLTDDS DIYWTAEVNE EGDTVVLSLK KFLKQDTYDV HLSLSDHGNK EQLTVIRATV CDCHGHVETC PGPWKGGFIL PVLGAVLALL FLLLVLLLLV RKKRKIKEPL LLPEDDTRDN VFYYGEEGGG EEDQDYDITQ LHRGLEARPE VVLRNDVAPT IIPTPMYRPR PANPDEIGNF IIENLKAANT DPTAPPYDTL LVFDYEGSGS DAASLSSLTS SASDQDQDYD YLNEWGSRFK KLADMYGGGE DD
3D Structure
ModBase 3D Structure for P22223
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Homo sapiens (Human)
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CDH3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CDH3 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Product Categories/Family for CDH3 recombinant protein
Transmembrane Protein
NCBI/Uniprot data below describe general gene information for CDH3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001304124.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001317195.1
[Other Products]
UniProt Primary Accession #
P22223
[Other Products]
UniProt Secondary Accession #
Q05DI6; B2R6F4[Other Products]
UniProt Related Accession #
P22223[Other Products]
Molecular Weight
86,552 Da
NCBI Official Full Name
cadherin-3 isoform 2
NCBI Official Synonym Full Names
cadherin 3
NCBI Official Symbol
CDH3??[Similar Products]
NCBI Official Synonym Symbols
CDHP; HJMD; PCAD
??[Similar Products]
NCBI Protein Information
cadherin-3
UniProt Protein Name
Cadherin-3
UniProt Synonym Protein Names
Placental cadherin; P-cadherin
UniProt Gene Name
CDH3??[Similar Products]
UniProt Synonym Gene Names
CDHP; P-cadherin??[Similar Products]
UniProt Entry Name
CADH3_HUMAN
NCBI Summary for CDH3
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015]
UniProt Comments for CDH3
CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: plasma membrane
Biological Process: cell adhesion; hair cycle process; keratinization; negative regulation of catagen; negative regulation of transforming growth factor-beta2 production; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of melanin biosynthetic process; positive regulation of monophenol monooxygenase activity; retinal homeostasis; Wnt receptor signaling pathway through beta-catenin
Disease: Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome; Hypotrichosis, Congenital, With Juvenile Macular Dystrophy
Research Articles on CDH3
1. The P-cadherin structure and packing arrangement provide new and valuable information towards the complete structural characterization of the cadherin dimerization pathway.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
