Product Name
Cadherin-3 (Cdh3), Recombinant Protein
Full Product Name
Recombinant Mouse Cadherin-3 (Cdh3)
Product Synonym Names
Cadherin-3; Placental cadherin; P-cadherin
Product Gene Name
Cdh3 recombinant protein
[Similar Products]
Product Synonym Gene Name
Cdh3; Cdhp[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
100-647
Sequence
E WVMPPIFVPE NGKGPFPQRL NQLKSNKDRG TKIFYSITGP GADSPPEGVF TIEKESGWLL LHMPLDREKI VKYELYGHAV SENGASVEEP MNISIIVTDQ NDNKPKFTQD TFRGSVLEGV MPGTSVMQVT ATDEDDAVNT YNGVVAYSIH SQEPKEPHDL MFTIHKSTGT ISVISSGLDR EKVPEYRLTV QATDMDGEGS TTTAEAVVQI LDANDNAPEF EPQKYEAWVP ENEVGHEVQR LTVTDLDVPN SPAWRATYHI VGGDDGDHFT ITTHPETNQG VLTTKKGLDF EAQDQHTLYV EVTNEAPFAV KLPTATATVV VHVKDVNEAP VFVPPSKVIE AQEGISIGEL VCIYTAQDPD KEDQKISYTI SRDPANWLAV DPDSGQITAA GILDREDEQF VKNNVYEVMV LATDSGNPPT TGTGTLLLTL TDINDHGPIP EPRQIIICNQ SPVPQVLNIT DKDLSPNSSP FQAQLTHDSD IYWMAEVSEK GDTVALSLKK FLKQDTYDLH LSLSDHGNRE QLTMIRATVC DCHGQVFNDC PRPWKGG
3D Structure
ModBase 3D Structure for P10287
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Cdh3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Cdh3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001032898.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001037809.5
[Other Products]
UniProt Primary Accession #
P10287
[Other Products]
UniProt Secondary Accession #
Q61465; Q8BSL6[Other Products]
UniProt Related Accession #
P10287[Other Products]
Molecular Weight
90,612 Da
NCBI Official Full Name
cadherin-3 isoform a preproprotein
NCBI Official Synonym Full Names
cadherin 3
NCBI Official Symbol
Cdh3??[Similar Products]
NCBI Official Synonym Symbols
Cadp; Cdhp; Pcad; AI385538; P-cadherin
??[Similar Products]
NCBI Protein Information
cadherin-3; placental cadherin; RPE-specific cadherin
UniProt Protein Name
Cadherin-3
UniProt Synonym Protein Names
Placental cadherin; P-cadherin
UniProt Gene Name
Cdh3??[Similar Products]
UniProt Synonym Gene Names
Cdhp; P-cadherin??[Similar Products]
UniProt Entry Name
CADH3_MOUSE
NCBI Summary for Cdh3
This gene encodes a calcium-dependent cell-cell adhesion protein containing five cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
UniProt Comments for Cdh3
CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: cell-cell adherens junction; membrane; cytoplasm; plasma membrane; integral to membrane
Molecular Function: metal ion binding; calcium ion binding
Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; hair cycle process; negative regulation of transforming growth factor-beta2 production; retinal homeostasis; cell-cell adhesion; negative regulation of catagen; positive regulation of monophenol monooxygenase activity; keratinization; positive regulation of melanin biosynthetic process; Wnt receptor signaling pathway through beta-catenin; cell adhesion; homophilic cell adhesion
Research Articles on Cdh3
1. P-cadherin is a direct PAX3-FOXO1A transcriptional target involved in Alveolar rhabdomyosarcoma aggressiveness.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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