For Research Use Only. Not for use in diagnostic procedures.

Store at 2 to 8 degree C for 6 months.

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Small volumes of IFNGR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS167318 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interferon gamma receptor 1 (IFNGR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IFNGR1. The ELISA analytical biochemical technique of the MBS167318 kit is based on IFNGR1 antibody-IFNGR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IFNGR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IFNGR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Intended Uses: This sandwich kit is for the accurate quantitative detection of human Interferon Gamma Receptor 1 (also known as IFNGR1) in serum, plasma, cell culture supernates, cell lysates, tissue homogenates.

Principles of the Assay: This kit is an Enzyme-Linked Immunosorbent Assay (ELISA). The plate has been pre-coated with human IFNGR1 antibody. IFNGR1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated human IFNGR1 Antibody is added and binds to IFNGR1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated IFNGR1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of human IFNGR1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.

21,542 Da

interferon gamma receptor 1

interferon gamma receptor 1

Interferon gamma receptor 1

IFN-gamma-R-alpha1 PublicationManual assertion based on opinion iniRef.9??[Similar Products]

This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]

Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550).

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