Product Name
BMPR1A, cDNA Clone
Full Product Name
BMPR1A cDNA Clone
Product Gene Name
BMPR1A cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgcctcagc tatacattta catcagatta ttgggagcct atttgttcat catttctcgt gttcaaggac agaatctgga tagtatgctt catggcactg ggatgaaatc agactccgac cagaaaaagt cagaaaatgg agtaacctta gcaccagagg ataccttgcc ttttttaaag tgctattgct cagggcactg tccagatgat gctattaata acacatgcat aactaatgga cattgctttg ccatcataga agaagatgac cagggagaaa ccacattagc ttcagggtgt atgaaatatg aaggatctga ttttcagtgc aaagattctc caaaagccca gctacgccgg acaatagaat gttgtcggac caatttatgt aaccagtatt tgcaacccac actgccccct gttgtcatag gtccgttttt tgatggcagc attcgatggc tggttttgct catttctatg gctgtctgca taattgctat gatcatcttc tccagctgct tttgttacaa acattattgc aagagcatct caagcagacg tcgttacaat cgtgatttgg aacaggatga agcatttatt ccagttggag aatcactaaa agaccttatt gaccagtcac aaagttctgg tagtgggtct ggactacctt tattggttca gcgaactatt gccaaacaga ttcagatggt ccggcaagtt ggtaaaggcc gatatggaga agtatggatg ggcaaatggc gtggcgaaaa agtggcggtg aaagtattct ttaccactga agaagccagc tggtttcgag aaacagaaat ctaccaaact gtgctaatgc gccatgaaaa catacttggt ttcatagcgg cagacattaa aggtacaggt tcctggactc agctctattt gattactgat taccatgaaa atggatctct ctatgacttc ctgaaatgtg ctacactgga caccagagcc ctgcttaaat tggcttattc agctgcctgt ggtctgtgcc acctgcacac agaaatttat ggcacccaag gaaagcccgc aattgctcat cgagacctaa agagcaaaaa catcctcatc aagaaaaatg ggagttgctg cattgctgac ctgggccttg ctgttaaatt caacagtgac acaaatgaag ttgatgtgcc cttgaatacc agggtgggca ccaaacgcta catggctccc gaagtgctgg acgaaagcct gaacaaaaac cacttccagc cctacatcat ggctgacatc tacagcttcg gcctaatcat ttgggagatg gctcgtcgtt gtatcacagg agggatcgtg gaagaatacc aattgccata ttacaacatg gtaccgagtg atccgtcata cgaagatatg cgtgaggttg tgtgtgtcaa acgtttgcgg ccaattgtgt ctaatcggtg gaacagtgat gaatgtctac gagcagtttt gaagctaatg tcagaatgct gggcccacaa tccagcctcc agactcacag cattgagaat taagaagacg cttgccaaga tggttgaatc ccaagatgta aaaatctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of BMPR1A cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for BMPR1A. It may not necessarily be applicable to this product.
NCBI Accession #
BC028383
[Other Products]
UniProt Secondary Accession #
Q8NEN8; A8K6U9[Other Products]
UniProt Related Accession #
P36894[Other Products]
Molecular Weight
60,198 Da
NCBI Official Full Name
Homo sapiens bone morphogenetic protein receptor, type IA, mRNA
NCBI Official Synonym Full Names
bone morphogenetic protein receptor type 1A
NCBI Official Symbol
BMPR1A??[Similar Products]
NCBI Official Synonym Symbols
ALK3; SKR5; CD292; ACVRLK3; 10q23del
??[Similar Products]
NCBI Protein Information
bone morphogenetic protein receptor type-1A
UniProt Protein Name
Bone morphogenetic protein receptor type-1A
UniProt Synonym Protein Names
Activin receptor-like kinase 3; ALK-3; Serine/threonine-protein kinase receptor R5; SKR5; CD_antigen: CD292
Protein Family
Bone morphogenetic protein receptor
UniProt Gene Name
BMPR1A??[Similar Products]
UniProt Synonym Gene Names
ACVRLK3; ALK3; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5??[Similar Products]
UniProt Entry Name
BMR1A_HUMAN
NCBI Summary for BMPR1A
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]
UniProt Comments for BMPR1A
BMPR1A: a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers.
Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily
Chromosomal Location of Human Ortholog: 10q22.3
Cellular Component: caveola; external side of plasma membrane; plasma membrane
Molecular Function: ATP binding; glycoprotein binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; SMAD binding; transmembrane receptor protein serine/threonine kinase activity
Biological Process: BMP signaling pathway; immune response; negative regulation of smooth muscle cell migration; positive regulation of bone mineralization; positive regulation of cardiac muscle cell proliferation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of cardiac muscle cell proliferation; transforming growth factor beta receptor signaling pathway
Disease: Juvenile Polyposis Syndrome; Polyposis Syndrome, Hereditary Mixed, 2
Research Articles on BMPR1A
1. Authors analyzed human databases from TCGA and survival data from microarrays to confirm BMPR1a tumor promoting functions, and found that high BMPR1a gene expression correlates with decreased survival regardless of molecular breast cancer subtype.
Precautions
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Disclaimer
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