BIOTIN-Conjugated Bone morphogenetic protein receptor type-1A Antibody; Activin A receptor type II like kinase 3 antibody; Activin receptor like kinase 3 antibody; ACVRLK 3 antibody; ALK 3 antibody; BMP type-1A receptor antibody; BMPR 1A antibody; Bmpr antibody; Bone morphogenetic protein receptor type-1A antibody; BR1a antibody; CD292 antibody; Serine threonine protein kinase receptor R5 antibody; SKR5 antibody; zBMPR IA antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Immobilized antigen affinity chromatography

0.5 ug/ul in antibody stabilization buffer (lot specific)

Store at -20 degree C for long term storage.

Small volumes of anti-BMPR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Overview: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.

Structure: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Expression: Highly expressed in skeletal muscle.

ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

ELISA: 1:10,000
IHC: 1:50-1:100
IP: 1:150
WB: 1:500

60,198 Da

bone morphogenetic protein receptor type 1A

bone morphogenetic protein receptor type-1A

Bone morphogenetic protein receptor type-1A

ACVRLK3; ALK3; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5??[Similar Products]

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.

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