Full Product Name
EXT1 Antibody
Product Gene Name
anti-EXT1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q16394
Species Reactivity
Human
Predicted: Mouse, Rat
Form/Format
Purified by protein affinity column containing 1% BSA and 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Other Notes
Small volumes of anti-EXT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EXT1 antibody
Rabbit polyclonal EXT1 (1) antibody was raised against a recombinate human EXT1 protein 5-162aa (BC001174).
Applications Tested/Suitable for anti-EXT1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-EXT1 antibody
ELISA: 1:20,000-1:80,000
WB: 1:200-1:1,000
Testing Data of anti-EXT1 antibody
NCBI/Uniprot data below describe general gene information for EXT1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000118.2
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NCBI GenBank Nucleotide #
NM_000127.2
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UniProt Primary Accession #
Q16394
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UniProt Secondary Accession #
Q9BVI9; B2R7V2[Other Products]
UniProt Related Accession #
Q16394[Other Products]
Molecular Weight
86,255 Da
NCBI Official Full Name
exostosin-1
NCBI Official Synonym Full Names
exostosin glycosyltransferase 1
NCBI Official Symbol
EXT1??[Similar Products]
NCBI Official Synonym Symbols
EXT; LGS; TTV; LGCR; TRPS2
??[Similar Products]
NCBI Protein Information
exostosin-1
UniProt Protein Name
Exostosin-1
UniProt Synonym Protein Names
Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostoses protein 1; Putative tumor suppressor protein EXT1
UniProt Gene Name
EXT1??[Similar Products]
NCBI Summary for EXT1
This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. [provided by RefSeq, Jul 2008]
UniProt Comments for EXT1
Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Product References and Citations for anti-EXT1 antibody
(1) Ciavarella, M., Coco, M., Baorda, F., et al. 20 novel point mutations and one large deletion in EXT1 and EXT2 genes: report of diagnostic screening in a large Italian cohort of patients affected by hereditary multiple exostosis. Gene 515 (2), 339-348 (2013).
Research Articles on EXT1
1. EXT1, a gene not previously linked to acute lymphoblastic leukemia via mutations, is a common interactor of NOTCH1 and FBXW7 regulating the NOTCH pathway in an FBXW7-dependend manner.
Precautions
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Disclaimer
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