Product Name
BMP-10, Monoclonal Antibody
Full Product Name
Mouse Anti-Human BMP-10
Product Synonym Names
BMP10; GMF
Product Gene Name
anti-BMP-10 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.12 (68865481..68871517, complement). Location: 2p13.3
3D Structure
ModBase 3D Structure for O95393
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Bone Morphogenetic Protein 10 (BMP-10).
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-BMP-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BMP-10 antibody
Bone morphogenetic protein 10 (BMP10) is a TGFbeta superfamily member whose expression is restricted to the developing and postnatal heart. It is synthesized as a 424 amino acid (aa) preproprotein with a putative 21 aa signal peptide, a 295 aa propeptide, and a 108 aa mature protein. Mature BMP10 is secreted as a 25 kDa disulfidelinked homodimer. Mature human BMP10 shares 98% aa sequence identity with mature mouse, and rat BMP10.
Applications Tested/Suitable for anti-BMP-10 antibody
Western Blot (WB), Neutr
NCBI/Uniprot data below describe general gene information for BMP-10. It may not necessarily be applicable to this product.
NCBI Accession #
NP_055297.1
[Other Products]
NCBI GenBank Nucleotide #
NM_014482.1
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UniProt Primary Accession #
O95393
[Other Products]
UniProt Secondary Accession #
Q53R17; Q6NTE0[Other Products]
UniProt Related Accession #
O95393[Other Products]
Molecular Weight
48,047 Da
NCBI Official Full Name
bone morphogenetic protein 10 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 10
NCBI Official Symbol
BMP10??[Similar Products]
NCBI Protein Information
bone morphogenetic protein 10
UniProt Protein Name
Bone morphogenetic protein 10
UniProt Gene Name
BMP10??[Similar Products]
UniProt Synonym Gene Names
BMP-10??[Similar Products]
UniProt Entry Name
BMP10_HUMAN
NCBI Summary for BMP-10
The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq, Jul 2008]
UniProt Comments for BMP-10
Function: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. Ref.4 Ref.5 Ref.6
Subunit structure: Homodimer; disulfide-linked
By similarity.
Subcellular location: Secreted
By similarity.
Tissue specificity: Detected in mammary epithelia (at protein level). Ref.6
Induction: Down-regulated in some breast cancer subtypes and breast cancer cell lines. Ref.6
Sequence similarities: Belongs to the TGF-beta family.
Research Articles on BMP-10
1. Low expression of bone morphogenetic protein-10 is associated with urothelial cancer of the bladder.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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