Product Name
BMP-10, Recombinant Protein
Full Product Name
Human BMP-10
Product Synonym Names
BMP-10; Bone morphogenic protein 10
Product Gene Name
BMP-10 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
NAKGNYCKRT PLYIDFKEIG WDSWIIAPPG YEAYECRGVC NYPLAE HLTP TKHAIIQALV HLKNSQKASK ACCVPTKLEP ISILYLDKGV V TYKFKYEGM AVSECGCR
Chromosome Location
Chromosome: 2; NC_000002.12 (68865481..68871517, complement). Location: 2p13.3
3D Structure
ModBase 3D Structure for O95393
Purity/Purification
>95% by SDS-PAGE & HPLC analysis
Biological Activity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. ?The expected ED50 for this effect is 4.0-6.0 ng/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of BMP-10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
BMP-10 recombinant protein
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation.? It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes.? BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.? Recombinant human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor.
Product Categories/Family for BMP-10 recombinant protein
Cytokines & Growth Factors
NCBI/Uniprot data below describe general gene information for BMP-10. It may not necessarily be applicable to this product.
NCBI Accession #
NP_055297.1
[Other Products]
NCBI GenBank Nucleotide #
NM_014482.1
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UniProt Primary Accession #
O95393
[Other Products]
UniProt Secondary Accession #
Q53R17; Q6NTE0[Other Products]
UniProt Related Accession #
O95393[Other Products]
Molecular Weight
48,047 Da
NCBI Official Full Name
bone morphogenetic protein 10 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 10
NCBI Official Symbol
BMP10??[Similar Products]
NCBI Protein Information
bone morphogenetic protein 10
UniProt Protein Name
Bone morphogenetic protein 10
UniProt Gene Name
BMP10??[Similar Products]
UniProt Synonym Gene Names
BMP-10??[Similar Products]
UniProt Entry Name
BMP10_HUMAN
NCBI Summary for BMP-10
The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq, Jul 2008]
UniProt Comments for BMP-10
Function: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. Ref.4 Ref.5 Ref.6
Subunit structure: Homodimer; disulfide-linked
By similarity.
Subcellular location: Secreted
By similarity.
Tissue specificity: Detected in mammary epithelia (at protein level). Ref.6
Induction: Down-regulated in some breast cancer subtypes and breast cancer cell lines. Ref.6
Sequence similarities: Belongs to the TGF-beta family.
Research Articles on BMP-10
1. Low expression of bone morphogenetic protein-10 is associated with urothelial cancer of the bladder.
Precautions
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Disclaimer
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