Product Name
Translation initiation factor eIF-2B subunit epsilon (Eif2b5), Recombinant Protein
Full Product Name
Recombinant Rat Translation initiation factor eIF-2B subunit epsilon (Eif2b5)
Product Gene Name
Eif2b5 recombinant protein
[Similar Products]
Product Synonym Gene Name
Eif2b5[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-716aa, full length protein
Sequence
MAATAAVPSA VGGRANKRGG GSGGGGTQGA EEEPPPPLQA VLVADSFDRR FFPISKDQPR VLLPLANVAL IDYTLEFLTA TGVQETFVFC CWKAAQIKEH LQKSKWCHPT SLNVVRIITS DLYRSLGDVL RDVDAKALVR SDFLLIYGDV VSNINISKAL EEHRLRRKLE KNVSVMTMVF KESSPSHPTR CHEDNVVLAV DSTTNRILHF QKTQGLRHFS FPLGLFQGSL DGVEIRYDLL DCHISICSPQ VAQLFTDNFD YQTRDDFVRG LLVNEEILGN QIHLHVTSRE YGARVSNLHM YSAVCADVIR RWVYPLTPEV NFTDSSTQSY THSRHNIYRG PEVSLGHGSV LEENVLLGAG TVVGSNCSIT NSVIGPNCHI GDNVVLDQAY LWQGVRVAAG AQIHQSLLCD RAEVKERVIL KPHCVLTSQV VVGPDIILPE GSVISLHPPD AEEDEDDGQF SDDSGADQEK EKVKLKGYNP AEVGPEGQGY LWKAEDVDEK EDEELRQSLW GLMINMEEES ETESERSVDP EELDSRAGSP QLDDIRVFQN EVLGTLQRGR EENISCDNLV LEINSLKYAY NISLKEVMQV LSHVVLEFPL QQVDGVLDPN RYCALLLPLL KAWSPVFRNY IKRAADHLEA LAAIEDFFLE HETLVPSLAK VLMAFYQLEI LAEETILSWF SQRDITDKGQ QLRKNQQLQR FIQWLREAEE ESSDDD
3D Structure
ModBase 3D Structure for Q64350
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Eif2b5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Eif2b5 recombinant protein
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.
NCBI/Uniprot data below describe general gene information for Eif2b5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_620221.2
[Other Products]
NCBI GenBank Nucleotide #
NM_138866.2
[Other Products]
UniProt Primary Accession #
Q64350
[Other Products]
UniProt Secondary Accession #
Q5RKL3[Other Products]
UniProt Related Accession #
Q64350[Other Products]
Molecular Weight
80,206 Da
NCBI Official Full Name
translation initiation factor eIF-2B subunit epsilon
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 2B subunit epsilon
NCBI Official Symbol
Eif2b5??[Similar Products]
NCBI Protein Information
translation initiation factor eIF-2B subunit epsilon
UniProt Protein Name
Translation initiation factor eIF-2B subunit epsilon
UniProt Synonym Protein Names
eIF-2B GDP-GTP exchange factor subunit epsilon
Protein Family
Translation initiation factor
UniProt Gene Name
Eif2b5??[Similar Products]
UniProt Synonym Gene Names
Eif2be??[Similar Products]
NCBI Summary for Eif2b5
subunit of eukaryotic initiation factor-2B, which plays a role in eukayrotic initiation factor 2 (eIF-2) recycling in translation initiation [RGD, Feb 2006]
UniProt Comments for Eif2b5
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Research Articles on Eif2b5
1. modulation of eIF2Bepsilon expression may be sufficient to correct deficits in skeletal muscle protein synthesis associated with sepsis and other muscle-wasting conditions
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
