MYL3; Myosin light chain 3; Cardiac myosin light chain 1; CMLC1; Myosin light chain 1; slow-twitch muscle B/ventricular isoform; MLC1SB; Ventricular/slow twitch myosin alkali light chain

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purified

1 mg/ml (lot specific)

Store at -20 degree C. Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-MYL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), ELISA (EIA)

WB: 1:500-1:2000, ELISA: 1:5000-1:20000

Western Blot analysis of HuvEc cells with MYL3 Polyclonal Antibody.

Calculated MW: 22
Observed MW: 22

myosin light chain 3

myosin light chain 3

Myosin light chain 3

MLC-lV/sb??[Similar Products]

MYL3_HUMAN

MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

MYL3: Regulatory light chain of myosin. Does not bind calcium. Defects in MYL3 are the cause of familial hypertrophic cardiomyopathy type 8 (CMH8). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.

Protein type: Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 3p21.3-p21.2

Cellular Component: A band; cytosol; I band; muscle myosin complex; sarcomere

Molecular Function: actin monomer binding; calcium ion binding; motor activity; myosin II heavy chain binding; structural constituent of muscle

Biological Process: cardiac muscle contraction; metabolic process; muscle filament sliding; positive regulation of ATPase activity; regulation of striated muscle contraction; regulation of the force of heart contraction; skeletal muscle development; ventricular cardiac muscle morphogenesis

Disease: Cardiomyopathy, Familial Hypertrophic, 8

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