Full Product Name
CAC1F Polyclonal Antibody
Product Synonym Names
Voltage-dependent L-type calcium channel subunit alpha-1F; Voltage-gated calcium channel subunit alpha Cav1.4; CACNA1F; CACNAF1
Product Gene Name
anti-CAC1F antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O60840
Species Reactivity
Human, Mouse
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 140-220
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CAC1F antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CAC1F antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CAC1F antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for CAC1F. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001243718.1
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NCBI GenBank Nucleotide #
NM_001256789.2
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UniProt Primary Accession #
O60840
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UniProt Secondary Accession #
O43901; O95226; Q9UHB1; A6NI29; F5CIQ9[Other Products]
UniProt Related Accession #
O60840[Other Products]
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit alpha-1F isoform 2
NCBI Official Synonym Full Names
calcium voltage-gated channel subunit alpha1 F
NCBI Official Symbol
CACNA1F??[Similar Products]
NCBI Official Synonym Symbols
JM8; OA2; AIED; COD3; COD4; JMC8; CORDX; CSNB2; CORDX3; CSNB2A; CSNBX2; Cav1.4; Cav1.4alpha1
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NCBI Protein Information
voltage-dependent L-type calcium channel subunit alpha-1F
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1F
UniProt Synonym Protein Names
Voltage-gated calcium channel subunit alpha Cav1.4
UniProt Gene Name
CACNA1F??[Similar Products]
NCBI Summary for CAC1F
This gene encodes a multipass transmembrane protein that functions as an alpha-1 subunit of the voltage-dependent calcium channel, which mediates the influx of calcium ions into the cell. The encoded protein forms a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Mutations in this gene can cause X-linked eye disorders, including congenital stationary night blindness type 2A, cone-rod dystropy, and Aland Island eye disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2013]
UniProt Comments for CAC1F
Isoform 1: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization.
Research Articles on CAC1F
1. These two cases demonstrate the clinical overlap between Leber congenital amaurosis and type 2 congenital stationary night blindness in infants and young children. Genetic testing is an essential tool in these cases and provides a more accurate diagnosis and prognosis for patients with inherited retinal degenerative disorders.
Precautions
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Disclaimer
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