Product Name
Natural resistance-associated macrophage protein 1 (Slc11a1), Recombinant Protein
Full Product Name
Recombinant Rat Natural resistance-associated macrophage protein 1 (Slc11a1), partial
Product Gene Name
Slc11a1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MIRDKNPQRV NRPSYGSISS LPSPAPQPEP SRNTYLSEKI PIPSTEQLLW VLLWATVLGL LCQRLAARLG VVTGKDLGEI CHLYYPKVPR ILLWLTIELA IVGSDMQEVI GTAISFNLLS AGRIPLWGGV LITIVDTFFF LFLDNYGLRK LEAFFGFLVT IMALTFGYEY VVARPSQGAL LKGLFLPSCP GCGQPELLQA VGIVGAIIMP HNIYLHSALV KSREVDRTRR GDVREANMYF LTEATIALFV SFIINLFVMA VFGQAFYQQT NEEAFNICAN SSLHNYAKIF PRDNNTVSVD IYQGGVILGC LFGPAALYIW AVGLLAAGQS STMTGTYAGQ FVMEGFLKLR WSRFARVLLT RSCAILPTVL VAVFRDLRDL SGLNDLLNVL QSLLLPFAVL PILTFTSMPA VMQEFANGWL SKVITSCIMA LVCAINLYFV ISYLPSLPHP AYFGLVALLA IGYLGLTAYL AWTCCIAHGA KFLTHSSHQR FLYGLPIEEQ EGREGSG
3D Structure
ModBase 3D Structure for P70553
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rattus norvegicus (Rat)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Slc11a1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Slc11a1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001026828.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001031658.1
[Other Products]
UniProt Primary Accession #
P70553
[Other Products]
UniProt Secondary Accession #
Q496Z6[Other Products]
UniProt Related Accession #
P70553[Other Products]
Molecular Weight
55,922 Da
NCBI Official Full Name
natural resistance-associated macrophage protein 1
NCBI Official Synonym Full Names
solute carrier family 11 member 1
NCBI Official Symbol
Slc11a1??[Similar Products]
NCBI Official Synonym Symbols
Bcg; Itg; Lsh; Nramp1
??[Similar Products]
NCBI Protein Information
natural resistance-associated macrophage protein 1
UniProt Protein Name
Natural resistance-associated macrophage protein 1
UniProt Synonym Protein Names
Solute carrier family 11 member 1
Protein Family
Natural resistance-associated macrophage protein
UniProt Gene Name
Slc11a1??[Similar Products]
UniProt Synonym Gene Names
Bcg; Nramp1; NRAMP 1??[Similar Products]
NCBI Summary for Slc11a1
putative metal ion transporter; mouse homolog is a macrophage protein associated with resistance or susceptibility to intracellular pathogens [RGD, Feb 2006]
UniProt Comments for Slc11a1
Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
