Inhbc; activin beta-C chain; inhibin beta C chain

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 12; NC_000012.12 (57434685..57452062). Location: 12q13.1

Monoclonal

IgG1

(4N17)

Mouse

Lyophilized

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-Activin-C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Activins are dimers consisting of two beta subunits. Several types of beta subunits have been described. These beta subunits can also heterodimerize with a constant alpha subunit to form Inhibins. The betac subunit homodimerizes to form Activin C andhas also been reported to heterodimerize with the betaA subunit.

Western Blot (WB)

38,238 Da

inhibin, beta C

inhibin beta C chain; activin beta-C chain

Inhibin beta C chain

INHBC_HUMAN

This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types. [provided by RefSeq, Jul 2008]

Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subunit structure: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only

By similarity.

Subcellular location: Secreted

By similarity.

Tissue specificity: Expressed in benign prostatic hyperplasia. Ref.4

Sequence similarities: Belongs to the TGF-beta family.

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