Product Name
Cardiac Troponin, I Subunit (TNNI3), Purified Protein
Full Product Name
Human Cardiac Troponin, I Subunit
Product Gene Name
TNNI3 purified protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P19429
Purity/Purification
> 95% based on SDS-PAGE
Purified.
Concentration
>0.2 mg/ml (lot specific)
Buffer
6M Urea, 75 mM Tris, pH 8.0, 15 mM mercaptoethanol, 10mM EDTA
Country of Origin
Human heart tissue from US donors (donors serum was tested and found negative for HBsAg, HIV-1, HIV-2, and HCV antibodies by FDA approved tests.)
Preparation and Storage
Store at -20 degree C or colder
Quality Manufacturing Systems
Manufactured under ISO QSR (Quality System Requirements) guidelines, compliant with ISO 13485:2016.
Other Notes
Small volumes of TNNI3 purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for TNNI3 purified protein
Purified Proteins and Immunoglobulins
Applications Tested/Suitable for TNNI3 purified protein
Western Blot (WB), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for TNNI3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000354.4
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NCBI GenBank Nucleotide #
NM_000363.4
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UniProt Primary Accession #
P19429
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UniProt Related Accession #
P19429[Other Products]
Molecular Weight
24,008 Da[Similar Products]
NCBI Official Full Name
troponin I, cardiac muscle
NCBI Official Synonym Full Names
troponin I3, cardiac type
NCBI Official Symbol
TNNI3??[Similar Products]
NCBI Official Synonym Symbols
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF
??[Similar Products]
NCBI Protein Information
troponin I, cardiac muscle
UniProt Protein Name
Troponin I, cardiac muscle
UniProt Synonym Protein Names
Cardiac troponin I
UniProt Gene Name
TNNI3??[Similar Products]
UniProt Synonym Gene Names
TNNC1??[Similar Products]
NCBI Summary for TNNI3
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
UniProt Comments for TNNI3
TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: cytosol; sarcomere; troponin complex
Molecular Function: actin binding; calcium channel inhibitor activity; calcium-dependent protein binding; protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding
Biological Process: cardiac muscle contraction; cellular calcium ion homeostasis; heart contraction; heart development; muscle filament sliding; negative regulation of ATPase activity; regulation of systemic arterial blood pressure by ischemic conditions; skeletal muscle contraction; vasculogenesis; ventricular cardiac muscle morphogenesis
Disease: Cardiomyopathy, Dilated, 1ff; Cardiomyopathy, Dilated, 2a; Cardiomyopathy, Familial Hypertrophic, 7; Cardiomyopathy, Familial Restrictive, 1
Research Articles on TNNI3
1. Sex, age, and systolic blood pressure belong to the strongest determinants of hs-cTnI in healthy *****s.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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