Full Product Name
BMP10 Antibody
Product Synonym Names
BMP-10; BMP10; Bone morphogenetic protein 10; MGC126783
Product Gene Name
anti-BMP10 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95393
Specificity
BMP10 antibody detects endogenous levels of total BMP10 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from Internal of human BMP10.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-BMP10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BMP10 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-BMP10 antibody
WB: 1:500-1:1000
ELISA: 1:1000
Western Blot (WB) of anti-BMP10 antibody
Western blot analysis of extracts from Jurkat cells, using BMP10 antibody.
NCBI/Uniprot data below describe general gene information for BMP10. It may not necessarily be applicable to this product.
NCBI Accession #
NP_055297.1
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NCBI GenBank Nucleotide #
NM_014482.2
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UniProt Primary Accession #
O95393
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UniProt Secondary Accession #
Q53R17; Q6NTE0[Other Products]
UniProt Related Accession #
O95393[Other Products]
Molecular Weight
48,047 Da
NCBI Official Full Name
bone morphogenetic protein 10 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 10
NCBI Official Symbol
BMP10??[Similar Products]
NCBI Protein Information
bone morphogenetic protein 10
UniProt Protein Name
Bone morphogenetic protein 10
Protein Family
Bone morphogenetic protein
UniProt Gene Name
BMP10??[Similar Products]
UniProt Synonym Gene Names
BMP-10??[Similar Products]
NCBI Summary for BMP10
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016]
UniProt Comments for BMP10
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
Research Articles on BMP10
1. Data suggest BMP9/GDF2 and BMP10 synergize with TNFA to increase monocyte recruitment to vascular endothelial cells; process appears to be mediated mainly via ALK2/ACVR1 (which exhibits protein kinase activity). These studies used in vitro flow monocyte adhesion assay. (BMP9 = growth differentiation factor 2; BMP10 = bone morphogenetic protein 10; TNFA = tumor necrosis factor alpha; ALK2/ACVR1 = activin A receptor type 1)
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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