Product Name
Homeobox protein Nkx-2.5 (Nkx2-5), Recombinant Protein
Full Product Name
Recombinant Rat Homeobox protein Nkx-2.5 (Nkx2-5)
Product Gene Name
Nkx2-5 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-318aa, Full length protein
Sequence
MFPSPALTHT PFSVKDILNL EQQQRSLAAG DLSARLEATL APASCMLAAF KPDGYSGPEA AAPGLAELRA ELGPAPSPPK CSPAFPTAPT FYPRAYGDPD PAKDPRADKK ELCALQKAVE LDKAETDGAE RRRPRRRRKP RVLFSQAQVY ELERRFKQQR YLSPAERDQL ASVLKLTSTQ VKIWFQNRRY KCKRQRQDQT LELLGPPPPP ARRIAVPVLV RDGKPCLGDS AAYAPAYGLG LNAYGYNAYP YPGYGGAACS PAYSCAAYPA APPAAHAPAA SANSNFVNFG VGDLNTVQSP GMPQGNSGVS TLHGIRAW
3D Structure
ModBase 3D Structure for O35767
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Nkx2-5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Nkx2-5 recombinant protein
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
NCBI/Uniprot data below describe general gene information for Nkx2-5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_446103.1
[Other Products]
NCBI GenBank Nucleotide #
NM_053651.1
[Other Products]
UniProt Primary Accession #
O35767
[Other Products]
UniProt Related Accession #
O35767[Other Products]
Molecular Weight
34,336 Da
NCBI Official Full Name
homeobox protein Nkx-2.5
NCBI Official Synonym Full Names
NK2 homeobox 5
NCBI Official Symbol
Nkx2-5??[Similar Products]
NCBI Official Synonym Symbols
Csx; Nkx2.5
??[Similar Products]
NCBI Protein Information
homeobox protein Nkx-2.5
UniProt Protein Name
Homeobox protein Nkx-2.5
UniProt Synonym Protein Names
Homeobox protein NK-2 homolog E
Protein Family
Homeobox protein
UniProt Gene Name
Nkx2-5??[Similar Products]
UniProt Synonym Gene Names
Csx; Nkx-2.5; Nkx2e; rNKx-2.5??[Similar Products]
NCBI Summary for Nkx2-5
homeobox transcription factor important for cardiac development [RGD, Feb 2006]
UniProt Comments for Nkx2-5
Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. Binds to the core DNA motif of NPPA promoter. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B. It is required for spleen development.
Research Articles on Nkx2-5
1. The data indicated that inhibition of Smad4 diminished both AdBMP2 induced and basal histone acetylation levels in the promoter regions of GATA4 and Nkx2.5.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
