TNNI3 Human, His; Cardiac Troponin-I Human Recombinant, His Tag; Troponin I cardiac muscle; Cardiac troponin I; TNNI3; TNNC1; CMH7; RCM1; cTnI; CMD2A; MGC116817

For Research Use Only. Not for use in diagnostic procedures.

E Coli

Protein is >95% pure as determined by 12% PAGE (coomassie staining).

TNNI3 protein solution (0.34 mg/mL) in PBS and 25 mM arginine.

TNNI3 although stable at 4°C for 1 week , should be stored below -18°C. Please prevent freeze thaw cycles.

Small volumes of TNNI3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Introduction: Troponin I (TnI), troponin T (TnT) and troponin C (TnC) form the troponin complex of the thin filaments of striated muscle. TnI is acts as the inhibitory subunit by blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains 3 genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TNNI3 gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in the TNNI3 gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).


Description: Recombinant Human TNNI3 protein produced in E Coli is a full length protein containing a total of 260 amino acids and fused to a 6 His Tag at C-terminus, migrating as a 27kDa band on SDS-PAGE.

Purified by proprietary chromatographic technique.

RECOMBINANT & NATURAL PROTEINS

troponin I3, cardiac type

troponin I, cardiac muscle

Troponin I, cardiac muscle

TNNC1??[Similar Products]

TNNI3_HUMAN

TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family.

Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: cytosol; sarcomere; troponin complex

Molecular Function: actin binding; calcium channel inhibitor activity; calcium-dependent protein binding; protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding

Biological Process: cardiac muscle contraction; cellular calcium ion homeostasis; heart contraction; heart development; muscle filament sliding; negative regulation of ATPase activity; regulation of systemic arterial blood pressure by ischemic conditions; skeletal muscle contraction; vasculogenesis; ventricular cardiac muscle morphogenesis

Disease: Cardiomyopathy, Dilated, 1ff; Cardiomyopathy, Dilated, 2a; Cardiomyopathy, Familial Hypertrophic, 7; Cardiomyopathy, Familial Restrictive, 1

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