For Research Use Only. Not for use in diagnostic procedures.

>98% by SDS PAGE and HPLC analysis

Purified recombinant protein - lyophilised

Approximate Protein Concentration: 0.1mg/ml after reconstitution (lot specific)

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.

Small volumes of CD141 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Recombinant Human CD141 antigen produced in HEK293 cells represents full length human CD141, otherwise known as Thrombomodulin, is a transmembrane glycoprotein specifically synthesized by endothelial cells, which plays a critical role in the activation/conversion of protein C into protein Ca, through the formation of a complex with the coagulation factor Thrombin. The subsequent cleavage and deactivation of the coagulation factors Va and factor VIIIa by protein Ca, acts to reduce Thrombin production and hence prevent further coagulation. Plasma levels of CD141 are increased in diabetes mellitus and SLE, and Thrombomodulin can correlate with the pathogenesis of the cardiovascular diseases thrombosis and atherosclerosis. Recombinant soluble Thrombomodulin contains 491 amino acid residues, including the extracellular domain of Thrombomodulin.

Functional Assays (FN)

60,329 Da

thrombomodulin

thrombomodulin; CD141 antigen; fetomodulin

Thrombomodulin

THRM; TM??[Similar Products]

TRBM_HUMAN

The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]

thrombomodulin: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THPH12). A hemostatic disorder characterized by a tendency to thrombosis. Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p11.2

Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; receptor activity; calcium ion binding

Biological Process: negative regulation of fibrinolysis; response to cAMP; negative regulation of blood coagulation; response to lipopolysaccharide; female pregnancy; signal transduction; blood coagulation; leukocyte migration; response to X-ray

Disease: Thrombophilia Due To Thrombomodulin Defect; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6

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