THRM; Thrombomodulin; TM; Fetomodulin; CD141

For Research Use Only. Not for use in diagnostic procedures.

Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.

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Small volumes of THBD elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS824732 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CD141 (THBD) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing THBD. The ELISA analytical biochemical technique of the MBS824732 kit is based on THBD antibody-THBD antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect THBD antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, THBD. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Sandwich ELISA for quantitative detection of Mouse CD141 concentrations.

Sandwich ELISA (SE)

61,868 Da

thrombomodulin

thrombomodulin; fetomodulin; snoRNA MBII-339

Thrombomodulin

TM??[Similar Products]

TRBM_MOUSE

thrombomodulin: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THPH12). A hemostatic disorder characterized by a tendency to thrombosis. Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.

Protein type: Membrane protein, integral

Cellular Component: extracellular space; cell surface; membrane; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: transmembrane receptor activity; calcium ion binding

Biological Process: embryonic development; hemostasis; negative regulation of blood coagulation; female pregnancy; negative regulation of coagulation; blood coagulation

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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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