For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2a

QBEND/40

Mouse

Tissue Culture Supernatant - liquid

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Small volumes of anti-CD141 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Mouse anti Human CD141 antibody, clone QBEND/40 recognizes all human endothelium tested. Preliminary evidence suggests that this antibody recognizes Thrombomodulin, but does not inhibit Thrombomodulin dependent activation of protein C.

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunohistology Paraffin*

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Immunohistology - Frozen: Minimum Dilution: 1/10; Maximum Dilution: 1/100
Flow Cytometry: Maximum Dilution: Neat
Immunohistology - Paraffin: Minimum Dilution: 1/10; Maximum Dilution: 1/50; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

Immunofluorescence staining of human tonsil cryosection with Mouse anti Human CD141 antibody, clone QBEND/40, red in A and Mouse anti Human CD21 (MBS212051), green in B. C is the merged image with nuclei counterstained blue using DAPI. High power

Immunoperoxidase staining of human Tonsil cryosection with Mouse anti Human CD141 antibody, clone QBEND/40 followed by the HISTAR detection system . Medium power

Immunoperoxidase staining of human Tonsil cryosection with Mouse anti Human CD141 antibody, clone QBEND/40 followed by the HISTAR detection system . Low power

Immunoperoxidase staining of human Tonsil cryosection with Mouse anti Human CD141 antibody, clone QBEND/40 followed by the HISTAR detection system . High power

Immunoperoxidase staining of human spleen cryosection with Mouse anti Human CD141 antibody, clone QBEND/40 followed by the HISTAR detection system . Low power

Immunofluorescence staining of human tonsil cryosection with Mouse anti Human CD141 antibody, clone QBEND/40, red in A and Mouse anti Human CD21 (MBS212051), green in B. C is the merged image with nuclei counterstained blue using DAPI. Low power

Staining of human lymph node. Formalin fixed, paraffin processed tissue with Mouse anti Human CD141 (MBS216516)

Immunoperoxidase staining of human Tonsil cryosection with Mouse anti Human CD141 antibody, clone QBEND/40 followed by the HISTAR detection system . High power

60,329 Da

thrombomodulin

thrombomodulin; CD141 antigen; fetomodulin

Thrombomodulin

THRM; TM??[Similar Products]

TRBM_HUMAN

The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]

thrombomodulin: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THPH12). A hemostatic disorder characterized by a tendency to thrombosis. Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p11.2

Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; calcium ion binding; receptor activity

Biological Process: response to cAMP; negative regulation of fibrinolysis; negative regulation of blood coagulation; response to lipopolysaccharide; female pregnancy; signal transduction; blood coagulation; leukocyte migration; response to X-ray

Disease: Thrombophilia Due To Thrombomodulin Defect; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6

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