Full Product Name
Polyclonal Antibody to CD141
Product Synonym Names
THRM; THBD; Thrombomodulin; Fetomodulin; CD141
Product Gene Name
anti-CD141 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P07204
Purity/Purification
Purified
Protein A Chromatography
Form/Format
25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05%?BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Immunogen Information
A partial length recombinant CD141 protein (amino acids 50-300) was used as the immunogen for this antibody.
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Other Notes
Small volumes of anti-CD141 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CD141 antibody
Antibodies; Cancer Marker
Applications Tested/Suitable for anti-CD141 antibody
Western Blot (WB)
Application Notes for anti-CD141 antibody
WB: 1-2 ug/ml
Western Blot (WB) of anti-CD141 antibody
Fig-1: Western blot analysis of?CD141. Anti-CD141?antibody (11-7576) was used at 2 ug/ml on h Testis lysate.
NCBI/Uniprot data below describe general gene information for CD141. It may not necessarily be applicable to this product.
NCBI Accession #
P07204.2
[Other Products]
UniProt Primary Accession #
P07204
[Other Products]
UniProt Secondary Accession #
Q8IV29; Q9UC32[Other Products]
UniProt Related Accession #
P07204[Other Products]
Molecular Weight
60,329 Da
NCBI Official Full Name
Thrombomodulin
NCBI Official Synonym Full Names
thrombomodulin
NCBI Official Symbol
THBD??[Similar Products]
NCBI Official Synonym Symbols
TM; THRM; AHUS6; BDCA3; CD141; THPH12
??[Similar Products]
NCBI Protein Information
thrombomodulin
UniProt Protein Name
Thrombomodulin
UniProt Synonym Protein Names
Fetomodulin; CD_antigen: CD141
UniProt Gene Name
THBD??[Similar Products]
UniProt Synonym Gene Names
THRM; TM??[Similar Products]
NCBI Summary for CD141
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
UniProt Comments for CD141
thrombomodulin: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THPH12). A hemostatic disorder characterized by a tendency to thrombosis. Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 20p11.21
Cellular Component: cell surface; plasma membrane
Molecular Function: protein binding; receptor activity
Biological Process: blood coagulation; leukocyte migration; negative regulation of blood coagulation; negative regulation of fibrinolysis
Disease: Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6; Thrombophilia Due To Thrombomodulin Defect
Research Articles on CD141
1. Case Report: thrombotic microangiopathy with mutations in complement factor I and thrombomodulin.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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