Product Synonym Names
Fetomodulin; CD141
Product Gene Name
anti-CD141 antibody
[Similar Products]
Product Synonym Gene Name
THBD[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P07204
Species Reactivity
Human, Mouse, Rat
Purity/Purification
ProA affinity purified
Storage Buffer
1*TBS (pH7.4), 1% BSA, 40% Glycerol.
Preservative
0.05% Sodium Azide.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-CD141 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CD141 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
NCBI/Uniprot data below describe general gene information for CD141. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000352.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000361.2
[Other Products]
UniProt Primary Accession #
P07204
[Other Products]
UniProt Secondary Accession #
Q8IV29; Q9UC32[Other Products]
UniProt Related Accession #
P07204[Other Products]
Molecular Weight
60,329 Da
NCBI Official Full Name
thrombomodulin
NCBI Official Synonym Full Names
thrombomodulin
NCBI Official Symbol
THBD??[Similar Products]
NCBI Official Synonym Symbols
TM; THRM; AHUS6; BDCA3; CD141; THPH12
??[Similar Products]
NCBI Protein Information
thrombomodulin
UniProt Protein Name
Thrombomodulin
UniProt Synonym Protein Names
Fetomodulin; CD_antigen: CD141
UniProt Gene Name
THBD??[Similar Products]
UniProt Synonym Gene Names
THRM; TM??[Similar Products]
NCBI Summary for CD141
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
UniProt Comments for CD141
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Research Articles on CD141
1. Lys 42, Lys 43, Lys 44 and Arg 12 are critical for the interaction of TAFI with the thrombin-thrombomodulin complex, which modulates its antifibrinolytic potential.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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