CMH7; RCM1; cTnI; CMD2A; TNNC1

For Research Use Only. Not for use in diagnostic procedures.

IgG1

3A10A12; 5C3A7

Mouse

Ascitic fluid containing 0.03% sodium azide.

Store at 4 degree C, for long term storage, store at-20 degree C

Small volumes of anti-cTnI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

cTnI has an apparent molecular weight of 22.5 kDa. cTnI is a candidate marker with acceptable sensitivity and specificity for AMI and other cardiac diseases. Troponin, a molecule that binds to the thin filament (actin) of striated muscle fibers, acts with intracellular calcium to control the interaction of the thin filament with the thick filament (myosin), thus regulating muscle contraction. Troponin I prevents muscle contraction in the absence of calcium, which has two skeletal muscle isoforms with considerable amino acid sequence homology. cTnI contains an additional N-terminal sequence and is highly specific for myocardium.

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Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

WB: 1:500-1:2000
IHC: 1:200-1:1000
ELISA: 1:10000

Figure 1. Western blot analysis using cTnI mouse mAb against truncated cTnI recombinant protein.

Figure 2. Immunohistochemical analysis of paraffin-embedded human normal cardiac muscle tissue, showing cytoplasmic localization using cTnI mouse mAb with DAB staining.

24,008 Da

troponin I3, cardiac type

troponin I, cardiac muscle

Troponin I, cardiac muscle

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Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

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