Product Name
SLC11A1, cDNA Clone
Full Product Name
SLC11A1 cDNA Clone
Product Gene Name
SLC11A1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggtgcgat gtcagctcac tgcaacctct acctcccagg tgccccgcac cgtcctctgg ctgaccatcg agctagccat tgtgggctcc gacatgcagg aagtcatcgg cacggccatt gcattcaatc tgctctcagc tggacgaatc ccactctggg gtggcgtcct catcaccatc gtggacacct tcttcttcct cttcctcgat aactacgggc tgcggaagct ggaagctttt tttggactcc ttataaccat tatggccttg acctttggct atgagtatgt ggtggcgcgt cctgagcagg gagcgcttct tcggggcctg ttcctgccct cgtgcccggg ctgcggccac cccgagctgc tgcaggcggt gggcattgtt ggcgccatca tcatgcccca caacatctac ctgcactcgg ccctggtcaa gtctcgagag atagaccggg cccgccgagc ggacatcaga gaagccaaca tgtacttcct gattgaggcc accatcgccc tgtccgtctc ctttatcatc aacctctttg tcatggctgt ctttgggcag gccttctacc agaaaaccaa ccaggctgcg ttcaacatct gtgccaacag cagcctccac gactacgcca agatcttccc catgaacaac gccaccgtgg ccgtggacat ttaccagggg ggcgtgatcc tgggctgcct gttcggcccc gcggccctct acatctgggc cataggtctc ctggcggctg ggcagagctc caccatgacg ggcacctacg cgggacagtt cgtgatggag ggcttcctga ggctgcggtg gtcacgcttc gcccgtgtcc tcctcacccg ctcctgcgcc atcctgccca ccgtgctcgt ggctgtcttc cgggacctga gggacttgtc gggcctcaat gatctgctca acgtgctgca gagcctgctg ctcccgttcg ccgtgctgcc catcctcacg ttcaccagca tgcccaccct catgcaggag tttgccaatg gcctgctgaa caaggtcgtc acctcttcca tcatggtgct agtctgcgcc atcaacctct acttcgtggt cagctatctg cccagcctgc cccaccctgc ctacttcggc cttgcagcct tgctggccgc agcctacctg ggcctcagca cctacctggt ctggacctgt tgccttgccc acggagccac ctttctggcc cacagctccc accaccactt cctgtatggg ctccttgaag aggaccagaa aggggagacc tctggctag
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SLC11A1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SLC11A1. It may not necessarily be applicable to this product.
NCBI Accession #
BC071165
[Other Products]
UniProt Secondary Accession #
C0H5Y3[Other Products]
UniProt Related Accession #
P49279[Other Products]
Molecular Weight
47,292 Da
NCBI Official Full Name
Homo sapiens solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1, mRNA
NCBI Official Synonym Full Names
solute carrier family 11 member 1
NCBI Official Symbol
SLC11A1??[Similar Products]
NCBI Official Synonym Symbols
LSH; NRAMP; NRAMP1
??[Similar Products]
NCBI Protein Information
natural resistance-associated macrophage protein 1
UniProt Protein Name
Natural resistance-associated macrophage protein 1
UniProt Synonym Protein Names
Solute carrier family 11 member 1
Protein Family
Natural resistance-associated macrophage protein
UniProt Gene Name
SLC11A1??[Similar Products]
UniProt Synonym Gene Names
LSH; NRAMP; NRAMP1; NRAMP 1??[Similar Products]
UniProt Entry Name
NRAM1_HUMAN
NCBI Summary for SLC11A1
This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for SLC11A1
SLC11A1: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. Belongs to the NRAMP family.
Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Vesicle; Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: late endosome; late endosome membrane; lysosome; phagocytic vesicle membrane; plasma membrane
Molecular Function: manganese ion transmembrane transporter activity; metal ion:hydrogen antiporter activity; protein homodimerization activity; transition metal ion transmembrane transporter activity
Biological Process: activation of protein kinase activity; antigen processing and presentation of peptide antigen; cell redox homeostasis; cellular cadmium ion homeostasis; cellular iron ion homeostasis; defense response to bacterium; defense response to Gram-negative bacterium; defense response to protozoan; inflammatory response; interleukin-2 production; interleukin-3 production; iron ion homeostasis; iron ion transport; L-arginine import; macrophage activation; manganese ion transport; MHC class II biosynthetic process; mRNA stabilization; negative regulation of cytokine production; nitrite transport; phagocytosis; positive regulation of cytokine production; positive regulation of dendritic cell antigen processing and presentation; positive regulation of interferon-gamma production; positive regulation of phagocytosis; positive regulation of T-helper 1 type immune response; positive regulation of transcription from RNA polymerase II promoter; respiratory burst; response to bacterium; response to lipopolysaccharide; T cell cytokine production; T cell proliferation during immune response; vacuolar acidification; wound healing
Disease: Buruli Ulcer, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To
Research Articles on SLC11A1
1. No significant difference was found for NRAMP1 and hGPX1 gene polymorphisms associated with recurrence time.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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