Product Name
COL14A1, Monoclonal Antibody
Full Product Name
COL14A1 (Collagen alpha-1(XIV) Chain, Undulin, UND)
Product Synonym Names
Anti -COL14A1 (Collagen alpha-1(XIV) Chain, Undulin, UND)
Product Gene Name
anti-COL14A1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
TRLRYNVISH DSIQISWKAP RGKFGGYKLL VTPTSGGKTN QLNLQNTATK AIIQGLMPDQ NYTVQIIAYN KDKESKPAQG QFRIKDL
Chromosome Location
Chromosome: 8; NC_000008.10 (121137347..121384273). Location: 8q23
3D Structure
ModBase 3D Structure for Q05707
Specificity
Recognizes human COL14A1.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Partial recombinant corresponding to aa34-120 from human COL14A1 (NP_066933) with GST tag. MW of the GST tag alone is 26kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-COL14A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-COL14A1 antibody
Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors.
Product Categories/Family for anti-COL14A1 antibody
Antibodies; Abs to Collagen
Applications Tested/Suitable for anti-COL14A1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-COL14A1 antibody
Suitable for use in ELISA and Western Blot.
NCBI/Uniprot data below describe general gene information for COL14A1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_066933.1
[Other Products]
NCBI GenBank Nucleotide #
NM_021110.2
[Other Products]
UniProt Primary Accession #
Q05707
[Other Products]
UniProt Secondary Accession #
O00260; O00261; O00262; Q05708; Q5XJ18; Q96C67; Q9UDF6; B2RU07[Other Products]
UniProt Related Accession #
Q05707[Other Products]
Molecular Weight
193,515 Da[Similar Products]
NCBI Official Full Name
collagen alpha-1(XIV) chain
NCBI Official Synonym Full Names
collagen, type XIV, alpha 1
NCBI Official Symbol
COL14A1??[Similar Products]
NCBI Official Synonym Symbols
UND
??[Similar Products]
NCBI Protein Information
collagen alpha-1(XIV) chain; collagen alpha-1(XIV) chain; undulin (fibronectin-tenascin-related)
UniProt Protein Name
Collagen alpha-1(XIV) chain
UniProt Synonym Protein Names
Undulin
UniProt Gene Name
COL14A1??[Similar Products]
UniProt Synonym Gene Names
UND??[Similar Products]
UniProt Entry Name
COEA1_HUMAN
NCBI Summary for COL14A1
This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. [provided by RefSeq, Jan 2013]
UniProt Comments for COL14A1
COL14A1: Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; Extracellular matrix
Chromosomal Location of Human Ortholog: 8q23
Cellular Component: collagen type XIV; extracellular matrix; extracellular space; proteinaceous extracellular matrix; collagen; endoplasmic reticulum lumen; extracellular region
Molecular Function: protein binding, bridging; collagen binding; extracellular matrix structural constituent
Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; cell-cell adhesion; collagen fibril organization; homeostasis of number of cells within a tissue
Research Articles on COL14A1
1. COL14A1 would be a casual gene for punctate palmoplantar keratoderma.
Precautions
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Disclaimer
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