Product Name
EDG3 (S1PR3), Polyclonal Antibody
Full Product Name
Anti-EDG3 Antibody
Product Synonym Names
EDG3; Sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P3; Endothelial differentiation G-protein coupled receptor 3; Sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3
Product Gene Name
anti-S1PR3 antibody
[Similar Products]
Antibody/Peptide Pairs
EDG3 peptide (MBS822614) is used for blocking the activity of EDG3 antibody (MBS820806)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99500
Specificity
Recognizes endogenous levels of EDG3 protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human EDG3. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-S1PR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-S1PR3 antibody
Rabbit polyclonal antibody to EDG3
Applications Tested/Suitable for anti-S1PR3 antibody
Western Blot (WB)
Application Notes for anti-S1PR3 antibody
WB (1/500 - 1/1000)
Western Blot (WB) of anti-S1PR3 antibody
Western blot analysis of EDG3 expression in SW480 (A), Caco2 (B), HepG2 (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for S1PR3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005217.2
[Other Products]
NCBI GenBank Nucleotide #
NM_005226.3
[Other Products]
UniProt Primary Accession #
Q99500
[Other Products]
UniProt Secondary Accession #
Q5SQD8; Q7Z5I2[Other Products]
UniProt Related Accession #
Q99500[Other Products]
Molecular Weight
42,250 Da
NCBI Official Full Name
sphingosine 1-phosphate receptor 3
NCBI Official Synonym Full Names
sphingosine-1-phosphate receptor 3
NCBI Official Symbol
S1PR3??[Similar Products]
NCBI Official Synonym Symbols
EDG3; LPB3; S1P3; EDG-3
??[Similar Products]
NCBI Protein Information
sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P receptor EDG3; S1P receptor Edg-3; sphingosine 1-phosphate receptor Edg-3; endothelial differentiation G-protein coupled receptor 3; G protein-coupled receptor, endothelial differentiation gene-3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
UniProt Protein Name
Sphingosine 1-phosphate receptor 3
UniProt Synonym Protein Names
Endothelial differentiation G-protein coupled receptor 3; Sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3
Protein Family
Sphingosine 1-phosphate receptor
UniProt Gene Name
S1PR3??[Similar Products]
UniProt Synonym Gene Names
EDG3; S1P receptor 3; S1P3; S1P receptor Edg-3??[Similar Products]
UniProt Entry Name
S1PR3_HUMAN
NCBI Summary for S1PR3
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
UniProt Comments for S1PR3
S1PR3: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9q22.1-q22.2
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: integrin binding; G-protein coupled receptor activity; lipid binding
Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; anatomical structure morphogenesis; regulation of interleukin-1 beta production; positive regulation of cell proliferation; cytokine production; G-protein signaling, adenylate cyclase inhibiting pathway; inflammatory response
Research Articles on S1PR3
1. we provide evidences that S1PR1/3, but not S1PR2, negatively regulate the expression of collagen in hMSCs using cellular and molecular approaches in vitro
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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