Full Product Name
Dsg2 Antibody - middle region
Product Gene Name
anti-DSG2 antibody
[Similar Products]
Product Synonym Gene Name
AA408168; D18Ertd293e[Similar Products]
Antibody/Peptide Pairs
Dsg2 peptide (MBS3232646) is used for blocking the activity of Dsg2 antibody (MBS3207680)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: TDADEVGSDN WLANFTFASG NEGGYFHIET DTQTNEGIVT LVKEVDYEEM
3D Structure
ModBase 3D Structure for O55111
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 93%; Dog: 92%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 93%; Rabbit: 85%; Rat: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Mouse Dsg2
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-DSG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DSG2 antibody
This is a rabbit polyclonal antibody against Dsg2. It was validated on Western Blot
Target Description: The function of this protein remains unknown.
Product Categories/Family for anti-DSG2 antibody
Polyclonal; Various;
Applications Tested/Suitable for anti-DSG2 antibody
Western Blot (WB)
Western Blot (WB) of anti-DSG2 antibody
Host: Rabbit
Target Name: Dsg2
Sample Type: Mouse Testis lysates
Antibody Dilution: 1.0ug/ml
NCBI/Uniprot data below describe general gene information for DSG2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_031909
[Other Products]
NCBI GenBank Nucleotide #
NM_007883
[Other Products]
UniProt Primary Accession #
O55111
[Other Products]
UniProt Related Accession #
O55111[Other Products]
NCBI Official Full Name
desmoglein-2 preproprotein
NCBI Official Synonym Full Names
desmoglein 2
NCBI Official Symbol
Dsg2??[Similar Products]
NCBI Official Synonym Symbols
AA408168; D18Ertd293e
??[Similar Products]
NCBI Protein Information
desmoglein-2
UniProt Protein Name
Desmoglein-2
Protein Family
Desmoglein
UniProt Gene Name
Dsg2??[Similar Products]
UniProt Entry Name
DSG2_MOUSE
NCBI Summary for DSG2
This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein die in utero. Mutant mice lacking a part of the extracellular adhesive domain of the encoded protein develop cardiac fibrosis and dilation. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]
UniProt Comments for DSG2
DSG2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10); also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB). A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Protein type: Calcium-binding; Membrane protein, integral; Cell adhesion
Cellular Component: desmosome; cell surface; membrane; apical plasma membrane; integral to membrane; plasma membrane; cell junction; lateral plasma membrane
Molecular Function: metal ion binding; calcium ion binding
Biological Process: homophilic cell adhesion; cell adhesion
Research Articles on DSG2
1. generated a Dsg2 loss-of-function strain (Dsg2 (lo/lo)) and observed that, in response to reduced levels of Dsg2: (i) CD31(+) endothelial cells in the pancreas are hypertrophic and exhibit altered morphology, (ii) bone marrow-derived endothelial colony formation is impaired, (iii) ex vivo vascular sprouting from aortic rings is reduced, and (iv) vessel formation in vitro and in vivo is attenuated
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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