For Research Use Only. Not for use in diagnostic procedures.

Cell Free Expression

Liquid containing glycerol

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Cybb recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Transmembrane Protein

This is a recombinant transmembrane protein expressed in a cell-free expression system.

65,305 Da

cytochrome b-245, beta polypeptide

cytochrome b-245 heavy chain

Cytochrome b-245 heavy chain

Cgd; Cytochrome b558 subunit beta??[Similar Products]

CY24B_MOUSE

This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]

CYBB: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of granulomatous disease,chronic, X-linked (CGD). A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life- threatening bacterial/fungal infections. Defects in CYBB are a cause of mycobacteriosis atypical X-linked type 2 (AMCBX2). A rare condition characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections.

Protein type: EC 1.-.-.-; Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass; Oxidoreductase

Cellular Component: cell soma; cytoplasm; dendrite; endoplasmic reticulum; Golgi apparatus; integral to membrane; integral to plasma membrane; intracellular; membrane; mitochondrion; NADPH oxidase complex; nuclear envelope; perinuclear region of cytoplasm; plasma membrane; rough endoplasmic reticulum

Molecular Function: electron carrier activity; F420H2 dehydrogenase activity; FAD binding; heme binding; malolactic enzyme activity; metal ion binding; N-ethylmaleimide reductase activity; oxidoreductase activity; protein binding; protein heterodimerization activity; sulfur oxygenase reductase activity; superoxide-generating NADPH oxidase activity; voltage-gated ion channel activity

Biological Process: hydrogen peroxide biosynthetic process; inflammatory response; innate immune response; ion transport; positive regulation of angiogenesis; positive regulation of tumor necrosis factor biosynthetic process; respiratory burst; response to drug; superoxide metabolic process; superoxide release; transport

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