Sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P3; Endothelial differentiation G-protein coupled receptor 3; Sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3; S1PR3; EDG3

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This EDG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human EDG3.

Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Vial Concentration: 2 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-S1PR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

EDG3 is a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.

Cardiovascular; Signal Transduction; GPCR Antibodies

Western Blot (WB), ELISA (EIA)

WB~~1:1000

The anti-EDG3 N-term Antibody is used in Western blot to detect EDG3 in mouse kidney lysate.

42250

sphingosine-1-phosphate receptor 3

sphingosine 1-phosphate receptor 3

Sphingosine 1-phosphate receptor 3

EDG3; S1P receptor 3; S1P3; S1P receptor Edg-3??[Similar Products]

S1PR3_HUMAN

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]

S1PR3: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q22.1-q22.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: integrin binding; G-protein coupled receptor activity; lipid binding

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; anatomical structure morphogenesis; regulation of interleukin-1 beta production; positive regulation of cell proliferation; cytokine production; G-protein signaling, adenylate cyclase inhibiting pathway; inflammatory response

Licht, T., et al., Blood 102(6):2099-2107 (2003).
Himmel, H.M., et al., Mol. Pharmacol. 58(2):449-454 (2000).
An, S., et al., J. Biol. Chem. 275(1):288-296 (2000).
Ancellin, N., et al., J. Biol. Chem. 274(27):18997-19002 (1999).
Lee, M.J., et al., Cell 99(3):301-312 (1999).

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