Product Name
Acid-sensing ion channel 2 (ASIC2), Recombinant Protein
Full Product Name
Recombinant Human Acid-sensing ion channel 2 (ASIC2), partial
Product Gene Name
ASIC2 recombinant protein
[Similar Products]
Product Synonym Gene Name
ASIC2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q16515
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ASIC2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ASIC2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001085.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001094.4
[Other Products]
UniProt Primary Accession #
Q16515
[Other Products]
UniProt Secondary Accession #
Q13553; Q6DJU1; Q8N3E2; E9PBX2[Other Products]
UniProt Related Accession #
Q16515[Other Products]
Molecular Weight
62,887 Da
NCBI Official Full Name
acid-sensing ion channel 2 isoform MDEG1
NCBI Official Synonym Full Names
acid sensing ion channel subunit 2
NCBI Official Symbol
ASIC2??[Similar Products]
NCBI Official Synonym Symbols
ACCN; BNC1; MDEG; ACCN1; BNaC1; ASIC2a; hBNaC1
??[Similar Products]
NCBI Protein Information
acid-sensing ion channel 2
UniProt Protein Name
Acid-sensing ion channel 2
UniProt Synonym Protein Names
Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; Brain sodium channel 1
Protein Family
Acid-sensing ion channel
UniProt Gene Name
ASIC2??[Similar Products]
UniProt Synonym Gene Names
ACCN; ACCN1; BNAC1; MDEG; MDEG??[Similar Products]
NCBI Summary for ASIC2
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
UniProt Comments for ASIC2
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li+ and K+. Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.MiscellaneousInhibited by anti-inflammatory drugs like salicylic acid (). Regulated by Zn2+.
Research Articles on ASIC2
1. The ASIC2 are involved in fear behaviours, learning and memory functions, and pain sensation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
